Description

4-Bromo-4′-chloro-2-fluoro-1,1′-biphenyl (CAS No. 134316-79-3) is a high-purity halogenated biphenyl compound with the molecular formula C₁₂H₇BrClF and IUPAC name 4-bromo-1-(4-chlorophenyl)-2-fluorobenzene. This specialized organic intermediate is meticulously synthesized for use in pharmaceutical research, material science, and advanced organic synthesis. Its unique structure, featuring bromo, chloro, and fluoro substituents, makes it a valuable building block for cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) and the development of liquid crystals or agrochemicals. Provided as a crystalline solid with ≥95% purity (HPLC), it is packaged under inert conditions to ensure stability. Suitable for researchers requiring precise functionalization of biphenyl scaffolds.

Properties

• CAS Number: 134316-79-3
• Complexity: 204
• IUPAC Name: 4-bromo-1-(4-chlorophenyl)-2-fluoro-benzene
• InChI: InChI=1S/C12H7BrClF/c13-9-3-6-11(12(15)7-9)8-1-4-10(14)5-2-8/h1-7H
• InChI Key: DZPFCTSSXBLCKQ-UHFFFAOYSA-N
• Exact Mass: 283.94037
• Molecular Formula: C12H7BrClF
• Molecular Weight: 285.54
• SMILES: C1=CC(=CC=C1C2=C(C=C(C=C2)Br)F)Cl
• Monoisotopic Mass: 283.94037
• Synonyms: 134316-79-3, 4-Bromo-4′-chloro-2-fluoro-1,1′-biphenyl, DTXSID001276674, DTXCID001707201, SCHEMBL8857820, 1,1′-Biphenyl, 4-bromo-4′-chloro-2-fluoro-, 4-Bromo-4a(2)-chloro-2-fluoro-1,1a(2)-biphenyl

Application

This compound serves as a key intermediate in the synthesis of complex organic molecules, particularly in pharmaceutical development for bioactive scaffolds. Its halogenated structure enables efficient participation in palladium-catalyzed cross-coupling reactions to construct conjugated systems. Researchers also utilize it in materials science for designing liquid crystalline compounds with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 2 of 2 companies. For more detailed information, please visit ECHA C&L website.

Hazard Classes and Categories

• Not Classified

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