Description

4-Bromo-3-(trifluoromethyl)aniline (CAS No. 393-36-2) is a high-purity aromatic amine derivative with the molecular formula C₇H₅BrF₃N. This compound features a bromo-substituted aniline core with a trifluoromethyl group at the 3-position, making it a versatile building block for pharmaceutical, agrochemical, and materials science applications. Its unique electronic and steric properties enable selective functionalization in cross-coupling reactions, nucleophilic substitutions, and other synthetic transformations. Supplied as a crystalline solid with ≥98% purity (HPLC), it is rigorously tested for consistency, stability, and low heavy metal content. Ideal for researchers developing fluorinated bioactive molecules or advanced materials. Store under inert atmosphere at 2-8°C to maintain optimal stability.

Properties

• CAS Number: 393-36-2
• Complexity: 159
• IUPAC Name: 4-bromo-3-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5BrF3N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2
• InChI Key: YGNISOAUPSJDJE-UHFFFAOYSA-N
• Exact Mass: 238.95575
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.02
• SMILES: C1=CC(=C(C=C1N)C(F)(F)F)Br
• Topological: 26
• Monoisotopic Mass: 238.95575
• Synonyms: 4-Bromo-3-(trifluoromethyl)aniline, 393-36-2, 5-Amino-2-bromobenzotrifluoride, 4-bromo-3-trifluoromethylaniline, 4-Bromo-3-trifluoromethyl-phenylamine, 3-trifluoromethyl-4-bromoaniline, Benzenamine, 4-bromo-3-(trifluoromethyl)-, 4-Amino-1-bromo-2-(trifluoromethyl)benzene, 4-Bromo-alpha,alpha,alpha-trifluoro-m-toluidine, NSC-88332, 4-bromo-3-(trifluoromethyl)benzenamine, 4-bromo-3-(trifluoromethyl)phenylamine, EN300-20854, MFCD00007827, NSC88332, EINECS 206-885-1, Z3SMJ2YC3E, NCIOpen2_005308, SCHEMBL204299, 3-amino-6-bromobenzotrifluoride, DTXSID50192540, 4-bromo-3-trifluoromethyl aniline, 4-bromo-3-trifluoromethyl-aniline, 4-bromo-3-(trifluoromethy)aniline, BDBM626094, 4-Bromo-3-(trifluoromethyl)-aniline, NSC 88332, SBB028146, VT1261, 4-Bromo-3-(trifluoromethyl)aniline #, AKOS000120787, AC-3663, CS-W020116, PS-7588, [4-bromo-3-(trifluoromethyl)phenyl]amine, 4-Bromo-3-(trifluoromethyl)aniline, 98%, DB-023970, A1847, NS00042718, ST50307033, m-Toluidine, 4-bromo-alpha,alpha,alpha-trifluoro-, 4-Bromo-.alpha.,.alpha.,.alpha.-trifluoro-m-toluidine, Z104483946

Application

4-Bromo-3-(trifluoromethyl)aniline serves as a key intermediate in Suzuki-Miyaura and Buchwald-Hartwig couplings for pharmaceutical candidates targeting CNS disorders. The trifluoromethyl group enhances metabolic stability in agrochemicals like herbicides and insecticides. Its electron-deficient aromatic system facilitates electrophilic substitutions in dye and polymer synthesis. Researchers also exploit its halogenated structure for PET radioligand development.

Safety and Hazards

GHS Hazard Statements

• H302 (94%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (86%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (94%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (84%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (94%)
• Acute Tox. 4 (86%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (94%)
• STOT SE 3 (84%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.