Description

(4-Bromo-3-fluorophenyl)methanamine hydrochloride (CAS No. 1214342-53-6) is a high-purity organic compound with the molecular formula C₇H₈BrClFN, widely used in pharmaceutical and chemical research. This hydrochloride salt features a bromo- and fluoro-substituted phenyl ring, making it a valuable intermediate in the synthesis of bioactive molecules, including drug candidates and agrochemicals. Its IUPAC name is (4-bromo-3-fluorophenyl)methanamine;hydrochloride, and it is supplied as a white to off-white crystalline powder with guaranteed ≥95% purity (HPLC). Suitable for use in cross-coupling reactions, amidation, and other functional group transformations, this compound is rigorously tested for quality, stability, and consistency. Packaged under inert conditions to ensure long-term stability, it is ideal for researchers requiring reliable building blocks for medicinal chemistry and material science applications.

Properties

• CAS Number: 1214342-53-6
• Complexity: 110
• IUPAC Name: (4-bromo-3-fluoro-phenyl)methanamine;hydrochloride
• InChI: InChI=1S/C7H7BrFN.ClH/c8-6-2-1-5(4-10)3-7(6)9;/h1-3H,4,10H2;1H
• InChI Key: YURPLAWBHIYAOX-UHFFFAOYSA-N
• Exact Mass: 238.95127
• Molecular Formula: C7H8BrClFN
• Molecular Weight: 240.50
• SMILES: C1=CC(=C(C=C1CN)F)Br.Cl
• Topological: 26
• Monoisotopic Mass: 238.95127
• Synonyms: (4-bromo-3-fluorophenyl)methanamine hydrochloride, 1214342-53-6, 823-440-2, (4-bromo-3-fluorophenyl)methanamine;hydrochloride, MFCD12546113, (4-Bromo-3-fluorophenyl)methanamine HCl, Benzenemethanamine, 4-bromo-3-fluoro-, hydrochloride (1:1), 4-Bromo-3-fluorobenzylamine Hydrochloride, SCHEMBL16037704, 1-(4-BROMO-3-FLUOROPHENYL)METHANAMINE HYDROCHLORIDE, CS1629, AKOS024462504, DS-7249, FB66565, AC-31255, SY070857, DB-145908, CS-0041618, EN300-75467, (4-bromo-3-fluorophenyl)methanaminehydrochloride, (4-Bromo-3-fluoro-phenyl)methanamine hydrochloride, Z2327126749

Application

(4-Bromo-3-fluorophenyl)methanamine hydrochloride serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and CNS-targeting drugs. Its halogenated aromatic structure enables participation in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Researchers also utilize it in the preparation of fluorinated analogs for SAR studies in drug discovery. The compound’s amine functionality allows for further derivatization into amides, sulfonamides, or ureas.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.