Description

4-Bromo-3-chlorophenol (CAS No. 13631-21-5) is a halogenated phenolic compound with the molecular formula C₆H₄BrClO. This high-purity reagent is widely utilized in organic synthesis, pharmaceutical research, and agrochemical development. The compound features both bromine and chlorine substituents on the phenolic ring, enhancing its reactivity for electrophilic aromatic substitution and coupling reactions. Available in crystalline or powder form, our product undergoes rigorous QC testing (including HPLC, GC-MS, and NMR) to ensure ≥98% purity. Suitable for use as an intermediate in the synthesis of advanced materials, dyes, and bioactive molecules. Packaged under inert gas to prevent degradation, with options for bulk quantities and custom synthesis.

Properties

• CAS Number: 13631-21-5
• Complexity: 99.1
• IUPAC Name: 4-bromo-3-chloro-phenol
• InChI: InChI=1S/C6H4BrClO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H
• InChI Key: FQEYHIPPYOSPLF-UHFFFAOYSA-N
• Exact Mass: 205.91341
• Molecular Formula: C6H4BrClO
• Molecular Weight: 207.45
• SMILES: C1=CC(=C(C=C1O)Cl)Br
• Topological: 20.2
• Monoisotopic Mass: 205.91341
• Synonyms: 4-Bromo-3-chlorophenol, 13631-21-5, DTXSID70426955, DTXCID00377789, 603-955-7, MFCD00070744, Phenol, 4-bromo-3-chloro-, 3-chloro-4-bromophenol, 4-bromo-3-chloro-phenol, SCHEMBL177738, 4-bromanyl-3-chloranyl-phenol, SCHEMBL5672010, SCHEMBL28787192, FQEYHIPPYOSPLF-UHFFFAOYSA-N, BCP05734, 4-Bromo-3-chlorophenol, AldrichCPR, BBL102205, CL8500, STL556004, AKOS015835305, CS-W007870, PS-8060, AC-16319, SY001199, DB-011300, B5816, ST50826824, EN300-115223, A807060

Application

4-Bromo-3-chlorophenol serves as a versatile building block in medicinal chemistry for constructing pharmacophores with antimicrobial properties. It is employed in Suzuki-Miyaura cross-coupling reactions to create biaryl structures for material science applications. Researchers also utilize this compound as a precursor in the development of liquid crystal displays (LCDs) and organic semiconductors.

Safety and Hazards

GHS Hazard Statements

• H302+H312 (75.7%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]
• H302 (94.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (89.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (97.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (94.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (94.6%)
• Acute Tox. 4 (89.2%)
• Skin Irrit. 2 (97.3%)
• Eye Irrit. 2 (97.3%)
• STOT SE 3 (94.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.