Description

4-Bromo-2,6-difluorophenol (CAS: 104197-13-9) is a high-purity halogenated phenol derivative with the molecular formula C₆H₃BrF₂O. This specialized organic compound is engineered for precision applications in pharmaceutical synthesis, agrochemical development, and advanced material science. Its unique bromo- and difluoro-substituted phenol structure enhances reactivity, making it a valuable intermediate in cross-coupling reactions, nucleophilic substitutions, and as a precursor for bioactive molecules. Packaged under inert conditions to ensure stability, our product undergoes rigorous QC testing (HPLC, GC/MS, NMR) to guarantee ≥98% purity, meeting the stringent demands of research and industrial applications. Available in gram to kilogram quantities with custom packaging options.

Properties

• CAS Number: 104197-13-9
• Complexity: 110
• IUPAC Name: 4-bromo-2,6-difluoro-phenol
• InChI: InChI=1S/C6H3BrF2O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H
• InChI Key: GPRPSJPFAAGLCA-UHFFFAOYSA-N
• Exact Mass: 207.93353
• Molecular Formula: C6H3BrF2O
• Molecular Weight: 208.99
• SMILES: C1=C(C=C(C(=C1F)O)F)Br
• Topological: 20.2
• Monoisotopic Mass: 207.93353
• Synonyms: 4-Bromo-2,6-difluorophenol, 104197-13-9, DTXSID10371253, DTXCID30322287, 642-788-4, 4-bromo-2,6-difluoro-phenol, MFCD00236213, Phenol, 4-bromo-2,6-difluoro-, 2,6 difluoro-4-bromophenol, SCHEMBL13029, 2,6-difluoro-4-bromo-phenol, SBB094133, AKOS015889715, AC-1586, CS-W015183, FB34211, AS-17680, SY030398, ST50827136, EN300-211087, Z1269203150

4-Bromo-2,6-difluorophenol serves as a key building block in medicinal chemistry for synthesizing fluorinated drug candidates, particularly kinase inhibitors and antimicrobial agents. Its electron-withdrawing substituents facilitate regioselective functionalization in Pd-catalyzed couplings (e.g., Suzuki-Miyaura). In material science, it acts as a monomer for flame-retardant polymers. Compatible with automated synthesis platforms for high-throughput screening.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (12.5%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.