Description

4-Bromo-2,6-difluorobenzaldehyde (CAS No. 537013-51-7) is a high-purity aromatic aldehyde compound with the molecular formula C₇H₃BrF₂O. This halogenated benzaldehyde derivative features bromo and fluoro substituents at the 4-, 2-, and 6-positions, making it a versatile building block for pharmaceutical, agrochemical, and materials science research. The compound is supplied as a crystalline solid with ≥95% purity (HPLC) and is rigorously tested for consistency in quality and performance. Ideal for use in Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions, this reagent is packaged under inert gas to ensure stability. Store in a cool, dry place away from light and moisture to maintain optimal shelf life.

Properties

• CAS Number: 537013-51-7
• Complexity: 141
• IUPAC Name: 4-bromo-2,6-difluoro-benzaldehyde
• InChI: InChI=1S/C7H3BrF2O/c8-4-1-6(9)5(3-11)7(10)2-4/h1-3H
• InChI Key: CZGVAISJIQNQEJ-UHFFFAOYSA-N
• Exact Mass: 219.93353
• Molecular Formula: C7H3BrF2O
• Molecular Weight: 221.00
• SMILES: C1=C(C=C(C(=C1F)C=O)F)Br
• Topological: 17.1
• Monoisotopic Mass: 219.93353
• Synonyms: 4-Bromo-2,6-difluorobenzaldehyde, 537013-51-7, DTXSID50378342, DTXCID00329369, 675-098-7, 4-bromo-2,6-difluorobenzylaldehyde, 4-bromo-2,6-difluoro-benzaldehyde, Benzaldehyde, 4-bromo-2,6-difluoro-, MFCD03094459, 2,6-Difluoro-4-bromobenzaldehyde, SCHEMBL578367, 4-Bromo 2,6-difluorobenzaldehyde, CZGVAISJIQNQEJ-UHFFFAOYSA-N, HY-Y1747, BBL103100, SBB064458, STL556910, AKOS015890078, AC-2290, CS-W009150, GS-3802, SB37561, 4-Bromo-2,6-difluorobenzaldehyde, 96%, SY036868, B3446, EN300-197815, Z1269231805

Application

4-Bromo-2,6-difluorobenzaldehyde serves as a key intermediate in the synthesis of bioactive molecules, particularly in the development of fluorinated pharmaceuticals and agrochemicals. Its reactive aldehyde group enables facile derivatization into alcohols, amines, and heterocycles. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to construct complex aromatic systems. It is also employed in materials science for designing fluorinated liquid crystals and organic electronic materials.

Safety and Hazards

GHS Hazard Statements

• H301 (88.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (11.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (11.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P316, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (88.2%)
• Skin Irrit. 2 (11.8%)
• Eye Irrit. 2 (11.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.