Description

4-Bromo-2,5-dichloropyridine (CAS No. 1184917-16-5) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂BrCl₂N. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromine and chlorine substituents on the pyridine ring, enables selective functionalization for the development of complex heterocyclic compounds. Available in >98% purity (HPLC), it is supplied as a white to off-white crystalline powder, packaged under inert conditions to ensure stability. Ideal for cross-coupling reactions (e.g., Suzuki, Stille), nucleophilic substitutions, and as a precursor for ligands or catalysts. Store at 2-8°C in a tightly sealed container to prevent moisture absorption.

Properties

• CAS Number: 1184917-16-5
• Complexity: 101
• IUPAC Name: 4-bromo-2,5-dichloro-pyridine
• InChI: InChI=1S/C5H2BrCl2N/c6-3-1-5(8)9-2-4(3)7/h1-2H
• InChI Key: KKWPWIYBRGEYEB-UHFFFAOYSA-N
• Exact Mass: 224.87477
• Molecular Formula: C5H2BrCl2N
• Molecular Weight: 226.88
• SMILES: C1=C(C(=CN=C1Cl)Cl)Br
• Topological: 12.9
• Monoisotopic Mass: 224.87477
• Synonyms: 4-Bromo-2,5-dichloropyridine, 1184917-16-5, 2,5-dichloro-4-bromopyridine, MFCD12911586, SCHEMBL12610138, DTXSID70657722, AKOS015891501, AB93003, DS-13530, SY037911, DB-061293, CS-0063815, EN300-1893969

Application

4-Bromo-2,5-dichloropyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. It is widely used in palladium-catalyzed cross-coupling reactions to construct biaryl systems for drug discovery. Researchers also employ it in the development of herbicides and fungicides due to its reactive halogen sites. Its pyridine core is valuable in material science for creating nitrogen-containing heterocycles with tailored electronic properties.

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