Description

4-Bromo-2,3-difluorophenol (CAS No. 144292-32-0) is a high-purity halogenated fluorophenol derivative with the molecular formula C₆H₃BrF₂O. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both bromine and fluorine substituents on the phenolic ring, enables selective functionalization for advanced intermediates. Available in >98% purity (GC), it is supplied as a crystalline solid with strict quality control to ensure batch-to-batch consistency. Ideal for Suzuki couplings, nucleophilic substitutions, and as a precursor for liquid crystal materials. Packaged under inert gas in amber glass vials to ensure stability.

• CAS: 144292-32-0
• Molecular Weight: 209.99 g/mol
• Synonym(s): 4-Bromo-2,3-difluorophenol, DTXSID10436896
• Storage: 2-8°C, protect from light and moisture

Properties

• CAS Number: 144292-32-0
• Complexity: 122
• IUPAC Name: 4-bromo-2,3-difluoro-phenol
• InChI: InChI=1S/C6H3BrF2O/c7-3-1-2-4(10)6(9)5(3)8/h1-2,10H
• InChI Key: JZAVCMMYGSROJP-UHFFFAOYSA-N
• Exact Mass: 207.93353
• Molecular Formula: C6H3BrF2O
• Molecular Weight: 208.99
• SMILES: C1=CC(=C(C(=C1O)F)F)Br
• Topological: 20.2
• Monoisotopic Mass: 207.93353
• Synonyms: 4-Bromo-2,3-difluorophenol, 144292-32-0, DTXSID10436896, DTXCID80387720, 678-845-5, 2,3-difluoro-4-bromophenol, 4-bromo-2,3-difluoro-phenol, Phenol, 4-bromo-2,3-difluoro-, MFCD08061907, SCHEMBL258026, 2,3-Difluoro-4-bromo phenol, JZAVCMMYGSROJP-UHFFFAOYSA-N, BBL100498, SBB094130, STL554292, AKOS005254216, AC-3751, CS-W007976, FD40718, 4-Bromo-2,3-difluorophenol, AldrichCPR, DS-12148, SY023065, DB-023741, D3913, EN300-110117

Application

4-Bromo-2,3-difluorophenol serves as a versatile intermediate in medicinal chemistry for the synthesis of bioactive molecules, particularly kinase inhibitors and antimicrobial agents. Its electron-deficient aromatic ring facilitates palladium-catalyzed cross-coupling reactions in drug discovery pipelines. Researchers also utilize it to develop advanced materials, including liquid crystals and OLED components, due to its halogen-rich structure. In agrochemical applications, it acts as a precursor for herbicides and fungicides with enhanced environmental stability.

Safety and Hazards

GHS Hazard Statements

• H302 (87.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (87.5%)
• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (12.5%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.