Description

4-Bromo-2,3-difluoroaniline (CAS No. 112279-72-8) is a high-purity halogenated aniline derivative with the molecular formula C₆H₄BrF₂N. This aromatic amine features a bromo substituent at the 4-position and two fluorine atoms at the 2- and 3-positions, offering unique electronic and steric properties for advanced synthetic applications. Ideal for pharmaceutical intermediates, agrochemical research, and materials science, this compound is supplied as a crystalline solid with ≥98% purity (HPLC). Packaged under inert gas to ensure stability, it is compatible with cross-coupling reactions, nucleophilic substitutions, and heterocycle synthesis. Available in research (1g-100g) and bulk quantities (1kg+) with optional custom purity and packaging.

Properties

• CAS Number: 112279-72-8
• Complexity: 122
• IUPAC Name: 4-bromo-2,3-difluoro-aniline
• InChI: InChI=1S/C6H4BrF2N/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2
• InChI Key: UEVLRVBHLWKNEN-UHFFFAOYSA-N
• Exact Mass: 206.94952
• Molecular Formula: C6H4BrF2N
• Molecular Weight: 208.00
• SMILES: C1=CC(=C(C(=C1N)F)F)Br
• Topological: 26
• Monoisotopic Mass: 206.94952
• Synonyms: 4-bromo-2,3-difluoroaniline, 112279-72-8, 4-bromo-2,3-difluorobenzenamine, DTXSID10562301, DTXCID30513077, 816-290-4, 2,3-difluoro-4-bromoaniline, MFCD09030643, 4-bromo-2,3-difluorophenylamine, 4-Bromo-2,3-difluoro-phenylamine, 2,3-Difluoro-4-bromo-aniline, 4-bromo-2,3-difluoro-aniline, 1-Amino-4-bromo-2,3-difluorobenzene, SCHEMBL441345, UEVLRVBHLWKNEN-UHFFFAOYSA-N, SBB070452, 4-Bromo-2 pound not3-difluoroaniline, AKOS005064061, AC-1566, DS-2256, SY046997, CS-0028730, EN300-199046, 4-Bromo-2,3-difluoroaniline;4-Bromo-2,3-difluoroaniline 97%

Application

4-Bromo-2,3-difluoroaniline serves as a key building block in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly kinase inhibitors and antimicrobial agents. Its electron-deficient aromatic ring facilitates Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) in agrochemical development. The compound is also employed in liquid crystal and OLED material research due to its halogen-fluorine substitution pattern influencing molecular polarity.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.