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Atomfair 4-Bromo-2,3-difluoroaniline C6H4BrF2N CAS 112279-72-8

4-Bromo-2,3-difluoroaniline (CAS No. 112279-72-8) is a high-purity halogenated aniline derivative with the molecular formula C6H4BrF2N . This aromatic amine features a bromo substituent at the 4-position and two fluorine atoms at the 2- and 3-positions, offering unique electronic and steric properties for advanced synthetic applications. Ideal for pharmaceutical intermediates, agrochemical research, and materials science, this compound is supplied as a crystalline solid with ≥98% purity (HPLC). Packaged under inert gas to ensure stability, it is compatible with cross-coupling reactions, nucleophilic substitutions, and heterocycle synthesis. Available in research (1g-100g) and bulk quantities (1kg+) with optional custom purity and packaging.

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Description

4-Bromo-2,3-difluoroaniline (CAS No. 112279-72-8) is a high-purity halogenated aniline derivative with the molecular formula C6H4BrF2N. This aromatic amine features a bromo substituent at the 4-position and two fluorine atoms at the 2- and 3-positions, offering unique electronic and steric properties for advanced synthetic applications. Ideal for pharmaceutical intermediates, agrochemical research, and materials science, this compound is supplied as a crystalline solid with ≥98% purity (HPLC). Packaged under inert gas to ensure stability, it is compatible with cross-coupling reactions, nucleophilic substitutions, and heterocycle synthesis. Available in research (1g-100g) and bulk quantities (1kg+) with optional custom purity and packaging.

Properties

  • CAS Number: 112279-72-8
  • Complexity: 122
  • IUPAC Name: 4-bromo-2,3-difluoro-aniline
  • InChI: InChI=1S/C6H4BrF2N/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2
  • InChI Key: UEVLRVBHLWKNEN-UHFFFAOYSA-N
  • Exact Mass: 206.94952
  • Molecular Formula: C6H4BrF2N
  • Molecular Weight: 208.00
  • SMILES: C1=CC(=C(C(=C1N)F)F)Br
  • Topological: 26
  • Monoisotopic Mass: 206.94952
  • Synonyms: 4-bromo-2,3-difluoroaniline, 112279-72-8, 4-bromo-2,3-difluorobenzenamine, DTXSID10562301, DTXCID30513077, 816-290-4, 2,3-difluoro-4-bromoaniline, MFCD09030643, 4-bromo-2,3-difluorophenylamine, 4-Bromo-2,3-difluoro-phenylamine, 2,3-Difluoro-4-bromo-aniline, 4-bromo-2,3-difluoro-aniline, 1-Amino-4-bromo-2,3-difluorobenzene, SCHEMBL441345, UEVLRVBHLWKNEN-UHFFFAOYSA-N, SBB070452, 4-Bromo-2 pound not3-difluoroaniline, AKOS005064061, AC-1566, DS-2256, SY046997, CS-0028730, EN300-199046, 4-Bromo-2,3-difluoroaniline;4-Bromo-2,3-difluoroaniline 97%

Application

4-Bromo-2,3-difluoroaniline serves as a key building block in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly kinase inhibitors and antimicrobial agents. Its electron-deficient aromatic ring facilitates Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) in agrochemical development. The compound is also employed in liquid crystal and OLED material research due to its halogen-fluorine substitution pattern influencing molecular polarity.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (50%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • Acute Tox. 4 (50%)
  • STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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