Description

4-Bromo-2-fluorobenzyl bromide (CAS No. 76283-09-5) is a high-purity halogenated aromatic compound with the molecular formula C₇H₅Br₂F. This versatile reagent is widely used in organic synthesis, pharmaceutical research, and material science due to its reactive benzyl bromide and bromo-fluorobenzene moieties. The compound is supplied as a clear to pale yellow liquid with a molecular weight of 267.92 g/mol, boiling point of approximately 120-122°C at 18 mmHg, and density of 1.87 g/cm³. It is moisture-sensitive and should be stored under inert atmosphere at 2-8°C. Our product is rigorously tested by HPLC, GC, and NMR to ensure ≥98% purity, making it ideal for demanding applications in medicinal chemistry and cross-coupling reactions.

Properties

• CAS Number: 76283-09-5
• Complexity: 108
• IUPAC Name: 4-bromo-1-(bromomethyl)-2-fluoro-benzene
• InChI: InChI=1S/C7H5Br2F/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
• InChI Key: XMHNLZXYPAULDF-UHFFFAOYSA-N
• Exact Mass: 267.87215
• Molecular Formula: C7H5Br2F
• Molecular Weight: 267.92
• SMILES: C1=CC(=C(C=C1Br)F)CBr
• Monoisotopic Mass: 265.87420
• Synonyms: 4-Bromo-2-fluorobenzyl bromide, 76283-09-5, 4-Bromo-1-(bromomethyl)-2-fluorobenzene, 2-fluoro-4-bromobenzyl bromide, EINECS 278-412-7, 0Z26XYC1JY, Benzene, 4-bromo-1-(bromomethyl)-2-fluoro-, 4-bromo-1-bromomethyl-2-fluorobenzene, .ALPHA.,4-DIBROMO-2-FLUOROTOLUENE, 4-BROMO-2-FLUORO-(BROMOMETHYL)BENZENE, alpha,4-Dibromo-2-fluorotoluene, 4-Bromo-1-(bromomethyl)-2-fluoro-benzene, MFCD00055467, 2-fluoro-4-bromobenzylbromide, DTXSID1057822, 4-Bromo-2-fluorobenzylbromide, 4,alpha-Dibromo-2-fluorotoluene, UNII-0Z26XYC1JY, 2-Fluoro-4-bromo-benzylbromide, 1-Bromo-4-bromomethyl-3-fluorobenzene, 4,a-Dibromo-2-fluorotoluene, SCHEMBL308050, 4-bromo-2-fluoro-benzylbromide, CHEMBL3188813, DTXCID2031611, 2-fluoro-4-bromo benzyl bromide, 4-bromo-2-fluoro benzyl bromide, Tox21_113803, AKOS005063873, 4-Bromo-2-fluorobenzyl bromide, 98%, CS-W007838, 4-bromo-1-bromomethyl-2-fluoro-benzene, NCGC00253679-01, AC-26172, AS-12825, CAS-76283-09-5, DB-024236, B1934, NS00058701, ST51040009, EN300-20942, SR-01000944786, SR-01000944786-1, Q27237365, InChI=1/C7H5Br2F/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H

Application

4-Bromo-2-fluorobenzyl bromide serves as a key building block in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for pharmaceutical intermediates. The compound is particularly valuable in the synthesis of fluorinated liquid crystals and bioactive molecules targeting CNS disorders. Its dual functionality allows for sequential functionalization of both the benzyl bromide and aromatic bromide positions.

Safety and Hazards

GHS Hazard Statements

• H301 (85.7%): Toxic if swallowed [Danger Acute toxicity, oral]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (85.7%)
• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.