Description

4-Bromo-2-fluoroanisole (CAS No. 2357-52-0) is a high-purity aromatic compound widely used in pharmaceutical and agrochemical research as a versatile intermediate. Its molecular formula, C₇H₆BrFO, features a bromo and fluoro substituent on a methoxybenzene backbone, enabling selective reactivity in cross-coupling reactions and electrophilic substitutions. This compound is supplied as a clear to pale yellow liquid with a purity of ≥97%, ensuring optimal performance in synthetic applications. Ideal for Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed transformations, it is packaged under inert gas to maintain stability. Suitable for laboratory use only—handle with appropriate personal protective equipment (PPE) and in compliance with GHS safety guidelines.

Properties

• CAS Number: 2357-52-0
• Complexity: 110
• IUPAC Name: 4-bromo-2-fluoro-1-methoxy-benzene
• InChI: InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
• InChI Key: DWNXGZBXFDNKOR-UHFFFAOYSA-N
• Exact Mass: 203.95861
• Molecular Formula: C7H6BrFO
• Molecular Weight: 205.02
• SMILES: COC1=C(C=C(C=C1)Br)F
• Topological: 9.2
• Monoisotopic Mass: 203.95861
• Synonyms: 4-Bromo-2-fluoroanisole, 2357-52-0, EINECS 219-096-2, DTXSID80178195, NSC 10329, DTXCID10100686, 219-096-2, 4-Bromo-2-fluoro-1-methoxybenzene, Benzene, 4-bromo-2-fluoro-1-methoxy-, 2-fluoro-4-bromoanisole, 1-Bromo-3-fluoro-4-methoxybenzene, 4-BROMO-2-FLUORO-1-METHOXY-BENZENE, MFCD00011710, NSC-10329, 2-fluoro-4-bromo anisole, NSC10329, 2-Fluor-4-bromanisol, o-fluoro-p-bromoanisole, 4-bromo-2-fluoro-anisole, F7J83Z8NHR, Anisole, 4-bromo-2-fluoro-, SCHEMBL282059, 3-fluoro-4-methoxybromobenzene, SCHEMBL1044895, SCHEMBL1095995, SCHEMBL29134432, 4-Bromo-2-fluoroanisole, 97%, DWNXGZBXFDNKOR-UHFFFAOYSA-, CS-D0985, SBB093394, 4-Bromo-2-fluoro-1-methoxybenzene #, AKOS008949054, AB01075, AC-3763, PS-8124, 4-bromo-2-fluoro-1-(methyloxy)benzene, SY016077, DB-028736, A1651, B1855, NS00048872, ST50405473, EN300-65442, Z54183592, F8880-5465, InChI=1/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3

4-Bromo-2-fluoroanisole serves as a key building block in the synthesis of bioactive molecules, particularly in drug discovery for functionalized aryl ethers. It is employed in palladium-catalyzed cross-coupling reactions to construct complex heterocycles. Researchers also utilize it to introduce bromo-fluoro motifs into scaffolds for PET radioligand development. Its stability under acidic conditions makes it suitable for multistep synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.