Description

4-Bromo-2-fluoro-6-nitrophenol (CAS No. 320-76-3) is a high-purity halogenated nitrophenol derivative with the molecular formula C₆H₃BrFNO₃. This compound is a versatile intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials. Its unique structure, featuring bromo, fluoro, and nitro functional groups on a phenolic ring, enables selective reactivity for cross-coupling reactions, nucleophilic substitutions, and other transformations. Suitable for researchers requiring precise functionalization, this product is rigorously tested for purity (typically ≥95% by HPLC or GC analysis) and is available in gram to kilogram quantities with customizable packaging. Store in a cool, dry place under inert conditions to ensure stability.

Properties

• CAS Number: 320-76-3
• Complexity: 186
• IUPAC Name: 4-bromo-2-fluoro-6-nitro-phenol
• InChI: InChI=1S/C6H3BrFNO3/c7-3-1-4(8)6(10)5(2-3)9(11)12/h1-2,10H
• InChI Key: ACQVEWFMUBXEMR-UHFFFAOYSA-N
• Exact Mass: 234.92803
• Molecular Formula: C6H3BrFNO3
• Molecular Weight: 235.99
• SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)F)Br
• Topological: 66.1
• Monoisotopic Mass: 234.92803
• Synonyms: 4-Bromo-2-fluoro-6-nitrophenol, 320-76-3, DTXSID90274152, DTXCID20196555, 625-008-7, MFCD00013372, Phenol, 4-bromo-2-fluoro-6-nitro-, SCHEMBL752254, SCHEMBL16654498, 4-bromo-2-fluoro 6-nitrophenol, 4-bromo-6-fluoro-2-nitrophenol, ACQVEWFMUBXEMR-UHFFFAOYSA-N, BBL101256, SBB064765, STL555052, AKOS005258104, CS-W006986, 4-Bromo-2-fluoro-6-nitrophenol, 97%, AS-18289, SY064734, DB-048151, EN300-314360

Application

4-Bromo-2-fluoro-6-nitrophenol is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its halogen and nitro groups facilitate Suzuki-Miyaura and Buchwald-Hartwig couplings for constructing complex heterocycles. Researchers also employ it in the development of fluorescent probes and dyes due to its electron-withdrawing properties. Additionally, it serves as a precursor in material science for designing advanced polymers and ligands.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (91.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (91.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (91.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (91.3%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.