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Atomfair 4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene C7H3BrF4O

Description 4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene (CAS No. 105529-58-6) is a high-purity halogenated aromatic compound with the molecular formula C7H3BrF4O . This specialty chemical features a benzene ring substituted with bromo, fluoro, and trifluoromethoxy functional groups, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its unique structure enables precise reactivity in cross-coupling reactions, nucleophilic substitutions, and fluorination processes. Supplied as a clear to pale-yellow liquid or low-melting solid, it is rigorously tested for purity (typically ??95% by GC or HPLC) and stability under recommended storage conditions (2-8??C under inert atmosphere). Ideal for use in Suzuki-Miyaura couplings, medicinal chemistry scaffolds, and agrochemical…

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Description

Description

4-Bromo-2-fluoro-1-(trifluoromethoxy)benzene (CAS No. 105529-58-6) is a high-purity halogenated aromatic compound with the molecular formula C7H3BrF4O. This specialty chemical features a benzene ring substituted with bromo, fluoro, and trifluoromethoxy functional groups, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its unique structure enables precise reactivity in cross-coupling reactions, nucleophilic substitutions, and fluorination processes. Supplied as a clear to pale-yellow liquid or low-melting solid, it is rigorously tested for purity (typically ??95% by GC or HPLC) and stability under recommended storage conditions (2-8??C under inert atmosphere). Ideal for use in Suzuki-Miyaura couplings, medicinal chemistry scaffolds, and agrochemical development. Available in research quantities (100mg to 100g) with optional custom packaging and purity optimization.

  • CAS No: 105529-58-6
  • Molecular Formula: C7H3BrF4O
  • Molecular Weight: 259.00
  • Exact Mass: 257.93034
  • Monoisotopic Mass: 257.93034
  • IUPAC Name: 4-bromo-2-fluoro-1-(trifluoromethoxy)benzene
  • SMILES: C1=CC(=C(C=C1Br)F)OC(F)(F)F
  • Synonyms: 4-bromo-2-fluoro-1-(trifluoromethoxy)benzene, 105529-58-6, 4-Bromo-2-fluoro-1-trifluoromethoxybenzene, DTXSID20381984, DTXCID20333009

Application

This compound serves as a versatile building block in pharmaceutical R&D, particularly for introducing fluorine-containing motifs into drug candidates to enhance metabolic stability and bioavailability. It is employed in palladium-catalyzed cross-coupling reactions to create biaryl structures common in kinase inhibitors. The trifluoromethoxy group’s electron-withdrawing properties make it valuable for modulating electronic characteristics in material science applications. Researchers also utilize it as a precursor for liquid crystal materials and agrochemical active ingredients requiring selective halogenation patterns.

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