Description

4-Bromo-2-cyanopyridine (CAS No. 62150-45-2) is a high-purity organic compound with the molecular formula C₆H₃BrN₂. This versatile heterocyclic building block features a bromine substituent at the 4-position and a cyano group at the 2-position of the pyridine ring, making it an essential intermediate for pharmaceutical synthesis, agrochemical development, and materials science research. Our product is rigorously tested to ensure >98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Ideal for nucleophilic substitution reactions, metal-catalyzed cross-couplings (e.g., Suzuki, Stille), and cyano-group transformations. Available in research quantities (100mg-25g) with optional custom packaging and purity options. MSDS and analytical certificates provided with every order.

Properties

• CAS Number: 62150-45-2
• Complexity: 137
• IUPAC Name: 4-bromopyridine-2-carbonitrile
• InChI: InChI=1S/C6H3BrN2/c7-5-1-2-9-6(3-5)4-8/h1-3H
• InChI Key: CZXDCTUSFIKLIJ-UHFFFAOYSA-N
• Exact Mass: 181.94796
• Molecular Formula: C6H3BrN2
• Molecular Weight: 183.01
• SMILES: C1=CN=C(C=C1Br)C#N
• Topological: 36.7
• Monoisotopic Mass: 181.94796
• Synonyms: 4-Bromo-2-cyanopyridine, 4-BROMO-2-PYRIDINECARBONITRILE, 688-035-3, 4-bromopyridine-2-carbonitrile, 62150-45-2, 4-bromopicolinonitrile, 4-BROMO-PYRIDINE-2-CARBONITRILE, MFCD04065805, 2-Pyridinecarbonitrile, 4-bromo-, 4-Bromo-2-cyano-pyridine, SCHEMBL504885, CHEMBL4563874, DTXSID40351205, CZXDCTUSFIKLIJ-UHFFFAOYSA-N, BCP27215, BBL102529, SBB016160, STL556332, AKOS000275960, AC-9582, CS-W019598, PB29307, PS-3946, SY015416, DB-006693, ST50206824, VU0509242-1, EN300-102445, F3099-7184

4-Bromo-2-cyanopyridine serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and CNS-targeting compounds. The bromo-cyano substitution pattern enables efficient derivatization via palladium-catalyzed cross-coupling reactions for medicinal chemistry applications. In material science, it functions as a building block for functionalized pyridine ligands in catalytic systems. The compound’s dual reactivity also makes it valuable for constructing heterocyclic frameworks in agrochemical research.

Safety and Hazards

GHS Hazard Statements

• H301 (22.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (77.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (11.1%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (66.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (77.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (77.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (11.1%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (66.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (77.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (22.2%)
• Acute Tox. 4 (77.8%)
• Acute Tox. 3 (11.1%)
• Acute Tox. 4 (66.7%)
• Skin Irrit. 2 (77.8%)
• Eye Irrit. 2A (77.8%)
• Acute Tox. 3 (11.1%)
• Acute Tox. 4 (66.7%)
• STOT SE 3 (77.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.