Description

4-Bromo-2-chloropyridine (CAS No. 73583-37-6) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrClN. This heterocyclic compound is widely used as a versatile building block in pharmaceutical, agrochemical, and material science research. Its reactive bromo and chloro substituents enable efficient cross-coupling reactions (e.g., Suzuki, Stille, or Buchwald-Hartwig) for the synthesis of complex molecules. Available at 97% purity, this product is rigorously quality-controlled via GC/HPLC and NMR to ensure batch-to-batch consistency. Suitable for use under inert atmospheres and stored at 2-8°C to maintain stability. Packaged in amber glass vials with secure closures to prevent moisture absorption and degradation.

Properties

• CAS Number: 73583-37-6
• Complexity: 78.8
• IUPAC Name: 4-bromo-2-chloro-pyridine
• InChI: InChI=1S/C5H3BrClN/c6-4-1-2-8-5(7)3-4/h1-3H
• InChI Key: ONHMWUXYIFULDO-UHFFFAOYSA-N
• Exact Mass: 190.91374
• Molecular Formula: C5H3BrClN
• Molecular Weight: 192.44
• SMILES: C1=CN=C(C=C1Br)Cl
• Topological: 12.9
• Monoisotopic Mass: 190.91374
• Synonyms: 4-Bromo-2-chloropyridine, 73583-37-6, DTXSID20397267, DTXCID50348126, 629-180-4, 2-Chloro-4-Bromopyridine, 4-bromo-2-chloro-pyridine, MFCD03840756, PYRIDINE, 4-BROMO-2-CHLORO-, SCHEMBL171912, SCHEMBL3608761, SCHEMBL4926053, SCHEMBL7757257, 4-Bromo-2-chloropyridine, 97%, BCP22210, CS-D0939, SBB054396, AKOS005145618, AB16617, AC-5166, PS-6261, HY-32752, SY006236, DB-006691, DB-239964, A9485, B2951, EN300-103561, F0001-5287, Z1255461858

4-Bromo-2-chloropyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and ligands for catalysis. It is employed in medicinal chemistry for the development of kinase inhibitors and antiviral agents. The compound’s dual halogen functionality allows selective functionalization in multi-step organic syntheses. Researchers also utilize it to create advanced materials, including liquid crystals and OLED components.

Safety and Hazards

GHS Hazard Statements

• H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (85.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (14.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Acute Tox. 4 (10.2%)
• Skin Irrit. 2 (98%)
• Eye Dam. 1 (85.7%)
• Eye Irrit. 2 (14.3%)
• Acute Tox. 4 (10.2%)
• STOT SE 3 (87.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.