Description

4-Bromo-1,2-difluorobenzene (CAS No. 348-61-8) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃BrF₂. This organofluorine building block is widely utilized in pharmaceutical, agrochemical, and materials science research due to its versatile reactivity. The compound features a benzene ring substituted with bromine at the para position and two fluorine atoms at the ortho positions, creating an electron-deficient aromatic system ideal for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to meet >98% purity standards (GC analysis) and is supplied in amber glass vials under inert atmosphere to ensure stability. Technical specifications include: molecular weight 193.00 g/mol, boiling point 168-170°C, density 1.72 g/cm³ at 25°C. Suitable for use in Suzuki-Miyaura couplings, Grignard reactions, and as a precursor for liquid crystal materials.

Properties

• CAS Number: 348-61-8
• Complexity: 97.1
• IUPAC Name: 4-bromo-1,2-difluoro-benzene
• InChI: InChI=1S/C6H3BrF2/c7-4-1-2-5(8)6(9)3-4/h1-3H
• InChI Key: YMQPKONILWWJQG-UHFFFAOYSA-N
• Exact Mass: 191.93862
• Molecular Formula: C6H3BrF2
• Molecular Weight: 192.99
• SMILES: C1=CC(=C(C=C1Br)F)F
• Monoisotopic Mass: 191.93862
• Synonyms: 4-Bromo-1,2-difluorobenzene, EINECS 206-481-5, DTXSID60188338, NSC 10251, DTXCID90110829, 206-481-5, 348-61-8, 1-Bromo-3,4-difluorobenzene, 3,4-Difluorobromobenzene, Benzene, 4-bromo-1,2-difluoro-, MFCD00000304, NSC-10251, 3,4-DIFLUORO-1-BROMOBENZENE, 3,4-difluoro-bromobenzene, 4-Bromo-1,2-difluoro-benzene, NSC10251, 3,4-difluorophenylbromide, 4-brom-1,2-difluorbenzol, A72M5VF2RD, SCHEMBL505542, SCHEMBL1101277, SCHEMBL1662818, SBB091521, 4-Bromo-1,2-difluorobenzene, 98%, AKOS000190590, CS-W015795, AC-23578, AS-12590, BP-10385, DB-006278, B1523, NS00042081, ST50405344, EN300-65435, D87816, 3,4-Difluorobromobenzene ;1-Bromo-3,4-difluorobenzene, InChI=1/C6H3BrF2/c7-4-1-2-5(8)6(9)3-4/h1-3

Application

4-Bromo-1,2-difluorobenzene serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates. The compound is valuable in material science for developing liquid crystals and organic semiconductors due to its stable aromatic structure with polarized halogen substituents. Researchers employ this building block in palladium-catalyzed cross-coupling reactions to create complex biaryl systems for agrochemical applications.

Safety and Hazards

GHS Hazard Statements

• H226: Flammable liquid and vapor [Warning Flammable liquids]
• H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]
• H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P273, P280, P303+P361+P353, P370+P378, P391, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (36.5%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (36.5%)
• Eye Irrit. 2 (63.5%)
• Acute Tox. 4 (36.5%)
• STOT SE 3 (62.2%)
• Aquatic Chronic 2 (36.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.