Description

4-Bromo-1-fluoro-2-nitrobenzene (CAS No. 364-73-8) is a high-purity aromatic compound with the molecular formula C₆H₃BrFNO₂. This versatile intermediate is widely used in organic synthesis, pharmaceutical research, and material science applications. The compound features a bromo- and fluoro-substituted nitrobenzene structure, making it an excellent building block for further functionalization via nucleophilic substitution or metal-catalyzed cross-coupling reactions.

Our product is rigorously tested to ensure >96% purity (GC) and is supplied as a crystalline solid with consistent lot-to-lot quality. Ideal for researchers developing novel compounds in medicinal chemistry, this reagent offers excellent reactivity for creating fluorinated pharmaceutical intermediates or specialty chemicals. Proper handling precautions should be observed due to its nitroaromatic properties.

Key applications include:

• Suzuki-Miyaura and other palladium-catalyzed couplings
• Nucleophilic aromatic substitution reactions
• Synthesis of fluorinated bioactive molecules
• Material science research

Properties

• CAS Number: 364-73-8
• Complexity: 161
• IUPAC Name: 4-bromo-1-fluoro-2-nitro-benzene
• InChI: InChI=1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
• InChI Key: UQEANKGXXSENNF-UHFFFAOYSA-N
• Exact Mass: 218.93312
• Molecular Formula: C6H3BrFNO2
• Molecular Weight: 220.00
• SMILES: C1=CC(=C(C=C1Br)[N+](=O)[O-])F
• Topological: 45.8
• Monoisotopic Mass: 218.93312
• Synonyms: 4-Bromo-1-fluoro-2-nitrobenzene, 364-73-8, DTXSID40371281, DTXCID00322315, 639-340-5, 5-Bromo-2-fluoronitrobenzene, 1-Bromo-4-fluoro-3-nitrobenzene, 2-fluoro-5-Bromonitrobenzene, MFCD00129165, 4-Bromo-1-fluoro-2-nitro-benzene, BENZENE, 4-BROMO-1-FLUORO-2-NITRO-, 4-bromo-1-fluoro-2-nitrobenzen, 5-bromo-fluoronitrobenzene, 5-bromo-2-fluronitrobenzene, SCHEMBL40706, SCHEMBL396694, 2-nitro 4-bromo fluorobenzene, 3-bromo-6-fluoro-nitrobenzene, 3-nitro-4-fluoro-bromobenzene, 5-bromo-2-fluoro-nitrobenzene, 5-bromo-2-fluoronitro benzene, 4-bromo-1-flouro-2-nitrobenzene, 4-bromo-1-fluoro -2-nitrobenzene, SBB063045, AKOS005259690, AKOS015888121, AC-2530, CS-W001134, FB34994, GS-3005, 4-Bromo-1-fluoro-2-nitrobenzene, 96%, B2075, ST50826726, EN300-54745, Z815304632, 4-Bromo-2-nitrofluorobenzene ;5-Bromo-2-fluoronitrobenzene;4-Fluoro-3-nitrobromobenzene

4-Bromo-1-fluoro-2-nitrobenzene serves as a key intermediate in pharmaceutical synthesis, particularly for introducing fluorine into drug candidates. The compound participates efficiently in palladium-catalyzed cross-coupling reactions to form biaryl structures common in medicinal agents. Researchers utilize its nitro group for subsequent reductions to anilines or as a directing group for further functionalization. The presence of both bromo and fluoro substituents allows selective displacement chemistry under different conditions.

Safety and Hazards

GHS Hazard Statements

• H302 (72.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (72.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (90.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (90.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (72.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (54.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (72.7%)
• Acute Tox. 4 (72.7%)
• Skin Irrit. 2 (90.9%)
• Eye Irrit. 2A (90.9%)
• Acute Tox. 4 (72.7%)
• STOT SE 3 (54.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.