Description

4-Amino-5-bromo-2-chloropyridine (CAS No. 857730-21-3) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₄BrClN₂. This heterocyclic compound, also known by its IUPAC name 5-bromo-2-chloropyridin-4-amine, is a versatile building block in pharmaceutical and agrochemical synthesis. The presence of reactive amino, bromo, and chloro substituents on the pyridine ring enables selective functionalization for the development of complex molecules. Our product is synthesized under stringent quality control measures, ensuring >98% purity by HPLC analysis. Supplied as an off-white to light brown crystalline powder, it is packaged under inert atmosphere to maintain stability. Ideal for researchers in medicinal chemistry, this compound is particularly valuable in the synthesis of kinase inhibitors and other biologically active heterocycles. Storage recommendations: -20°C under argon, protected from light and moisture.

Properties

• CAS Number: 857730-21-3
• Complexity: 101
• IUPAC Name: 5-bromo-2-chloro-pyridin-4-amine
• InChI: InChI=1S/C5H4BrClN2/c6-3-2-9-5(7)1-4(3)8/h1-2H,(H2,8,9)
• InChI Key: MGZWZNBANVSZLM-UHFFFAOYSA-N
• Exact Mass: 205.92464
• Molecular Formula: C5H4BrClN2
• Molecular Weight: 207.45
• SMILES: C1=C(C(=CN=C1Cl)Br)N
• Topological: 38.9
• Monoisotopic Mass: 205.92464
• Synonyms: 4-Amino-5-bromo-2-chloropyridine, 640-751-7, 857730-21-3, 5-bromo-2-chloropyridin-4-amine, 5-Bromo-2-chloro-4-pyridinamine, MFCD09037459, 4-Pyridinamine, 5-bromo-2-chloro-, SCHEMBL248674, DTXSID10653228, MGZWZNBANVSZLM-UHFFFAOYSA-N, 5-bromo-2-chloro-4-aminopyridine, BCP26549, CS-D0869, BBL103757, STL557567, AKOS005072785, AC-5983, FD-0719, PB26428, 4-Amino-5-bromo-2-chloropyridine, 97%, SY022757, DB-000482, EN300-172174, A1-01493

Application

4-Amino-5-bromo-2-chloropyridine serves as a key intermediate in pharmaceutical research, particularly in the development of protein kinase inhibitors for oncology applications. The compound’s multiple reactive sites allow for sequential cross-coupling reactions in drug discovery programs. It has shown utility in synthesizing potential therapeutic agents targeting inflammatory diseases and central nervous system disorders. Researchers also employ this building block in material science for creating specialized ligands in catalytic systems.

Safety and Hazards

GHS Hazard Statements

• H301 (89.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (10.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (13%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (89.1%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (13%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.