Description

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl Acetate (CAS No. 480424-70-2) is a high-purity boronic ester derivative with the molecular formula C₁₄H₁₉BO₄. This compound features a phenyl acetate moiety linked to a 4,4,5,5-tetramethyl-1,3,2-dioxaborolane group, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its stable dioxaborolane ring ensures excellent shelf life and compatibility with various reaction conditions, including Suzuki-Miyaura cross-coupling reactions. Ideal for researchers seeking reliable boron-containing building blocks, this product is rigorously tested for purity (typically ≥95% by HPLC or GC) and is available in convenient quantities for laboratory use. Store under inert conditions to maintain stability.

Properties

• CAS Number: 480424-70-2
• Complexity: 329
• IUPAC Name: [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] acetate
• InChI: InChI=1S/C14H19BO4/c1-10(16)17-12-8-6-11(7-9-12)15-18-13(2,3)14(4,5)19-15/h6-9H,1-5H3
• InChI Key: KHBAJCWEQNVCSN-UHFFFAOYSA-N
• Exact Mass: 262.1376392
• Molecular Formula: C14H19BO4
• Molecular Weight: 262.11
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)OC(=O)C
• Topological: 44.8
• Monoisotopic Mass: 262.1376392
• Synonyms: 480424-70-2, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl acetate, DTXSID80378830, DTXCID30329857, 808-214-3, 4-Acetoxyphenylboronic acid pinacol ester, [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] Acetate, 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl acetate, 4-Acetoxyphenylboronic acid, pinacol ester, MFCD03453060, 4-Acetoxybenzeneboronic acid pinacol ester, 2-(4-Acetoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, (4-ACETOXYPHENYL)BORONIC ACID PINACOL ESTER, SCHEMBL311872, KHBAJCWEQNVCSN-UHFFFAOYSA-N, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYLACETATE, AKOS015894332, AB15490, AS-2793, CS-W000940, AC-33904, SY057168, DB-016033, T3224, 4-Acetoxyphenylboronic acid pinacol ester, 97%, 4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)phenyl acetate, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenylacetate

Application

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl Acetate is widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds. It serves as a protected boronic acid derivative in medicinal chemistry, enabling the introduction of phenyl acetate groups into complex molecules. Researchers also employ it in polymer science and materials chemistry for functionalizing aromatic frameworks.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.