Description

4′-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide (CAS No. 214360-60-8) is a high-purity boronic ester derivative with the molecular formula C₁₄H₂₀BNO₃. This compound features a stable dioxaborolane ring and an acetamide functional group, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its IUPAC name is N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide. The tetramethyl substitution on the dioxaborolane ring enhances its stability and shelf life, while the para-substituted phenylacetamide moiety allows for further functionalization via Suzuki-Miyaura cross-coupling reactions. Ideal for researchers in medicinal chemistry and material science, this product is rigorously tested for purity and consistency, ensuring reliable performance in demanding applications.

Properties

• CAS Number: 214360-60-8
• Complexity: 333
• IUPAC Name: N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide
• InChI: InChI=1S/C14H20BNO3/c1-10(17)16-12-8-6-11(7-9-12)15-18-13(2,3)14(4,5)19-15/h6-9H,1-5H3,(H,16,17)
• InChI Key: ANGKVUVZQVUVJO-UHFFFAOYSA-N
• Exact Mass: 261.1536237
• Molecular Formula: C14H20BNO3
• Molecular Weight: 261.13
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)NC(=O)C
• Topological: 47.6
• Monoisotopic Mass: 261.1536237
• Synonyms: 4′-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide, 625-791-5, 214360-60-8, N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide, 4-Acetamidophenylboronic acid pinacol ester, 4-Acetylaminophenylboronic acid, pinacol ester, 4-ACETYLAMINOPHENYLBORONIC ACID PINACOL ESTER, MFCD02093722, N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide, 4-(Acetamido)benzeneboronic acid, pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide, ACETAMIDE, N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]-, (4-ACETAMIDOPHENYL)BORONIC ACID PINACOL ESTER, SCHEMBL1284377, DTXSID80370399, AKOS015888391, N-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetamide, AS-2604, SY025526, DB-045583, DB-305011, CS-0097879, T1950, 10.14272/ANGKVUVZQVUVJO-UHFFFAOYSA-N, EN300-3256203, 4-Acetamidophenylboronic acid pinacol ester, 97%, doi:10.14272/ANGKVUVZQVUVJO-UHFFFAOYSA-N, 2-(4-Acetamidophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-acetanilide, 4′-(4 pound not4 pound not5 pound not5-Tetramethyl-1 pound not3 pound not2-dioxaborolan-2-yl)acetanilide

Application

4′-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide is widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds. It serves as a building block in pharmaceutical research, particularly for developing kinase inhibitors and other bioactive molecules. The compound’s stability and reactivity also make it suitable for material science applications, such as polymer and OLED material synthesis.

Safety and Hazards

GHS Hazard Statements

• H315 (97.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (97.6%)
• Eye Irrit. 2 (97.6%)
• STOT SE 3 (95.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.