Description

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 269410-08-4) is a high-purity boronic ester derivative widely used in organic synthesis, pharmaceutical research, and materials science. This compound features a pyrazole ring tethered to a pinacol boronate group, making it an excellent building block for Suzuki-Miyaura cross-coupling reactions. With the molecular formula C₉H₁₅BN₂O₂, it offers exceptional stability and reactivity under controlled conditions. Ideal for researchers developing novel heterocyclic compounds, this reagent is rigorously tested for quality and supplied in sealed packaging to ensure integrity. Store under inert conditions to maintain optimal performance.

Properties

• CAS Number: 269410-08-4
• Complexity: 217
• IUPAC Name: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• InChI: InChI=1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)
• InChI Key: TVOJIBGZFYMWDT-UHFFFAOYSA-N
• Exact Mass: 194.1226579
• Molecular Formula: C9H15BN2O2
• Molecular Weight: 194.04
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CNN=C2
• Topological: 47.1
• Monoisotopic Mass: 194.1226579
• Synonyms: 269410-08-4, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, DTXSID40378836, DTXCID40329863, 629-131-7, Pyrazole-4-boronic acid pinacol ester, 4-Pyrazoleboronic acid pinacol ester, 1h-pyrazole-4-boronic acid pinacol ester, 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, pyrazole-4-boronic acid, pinacol ester, MFCD03453063, 1h-pyrazole-4-boronic acid, pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, 4,4,5,5-Tetramethyl-2-(1H-pyrazol-4-yl)-1,3,2-dioxaborolane, 1H-Pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, SCHEMBL98961, (1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER, 4U3BSC724T, TVOJIBGZFYMWDT-UHFFFAOYSA-N, BCP02712, CS-D1164, HY-I0314, BBL101319, SBB091668, STL555115, 4-pyrazole boronic acid pinacol ester, 4-pyrazolyl boronic acid pinacol ester, AKOS005258370, AB15498, AS-2979, FP11151, SB11372, NCGC00663094-01, AC-22285, BP-12124, PD199973, SY004218, 4-Pyrazoleboronic acid pinacol ester, 97%, DB-008348, T2756, EN300-92082, PYRAZOL-4-YLBORONIC ACID PINACOL ESTER, A22310, 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1 H-pyrazole, Z1255391278, 4,4,5,5-tetramethyl-2-pyrazol-4-yl-1,3,2-dioxaborolane, 2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan2-yl)-1H-pyrazole, 2-(1H-Pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 4,4,5,5-Tetramethyl-2-(1H-pyrazol-4-yl)[1,3,2]dioxaborolane, 4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole, 4-(4,4,5,5-tetramethyl 1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 4-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-1H-pyrazole, 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) 1H-pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-H-pyrazole, 4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole, 4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-2-YL)-1,3,2-DIOXABOROLANE

This compound is primarily employed as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its pinacol boronate moiety facilitates efficient cross-coupling reactions, enabling the construction of complex molecular architectures. Researchers utilize it in medicinal chemistry for designing bioactive pyrazole derivatives. It also finds applications in polymer chemistry and ligand design for catalysis. Handle with standard laboratory precautions to avoid moisture exposure.

Safety and Hazards

GHS Hazard Statements

• H315 (98.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (96.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (98.1%)
• Eye Irrit. 2 (98.1%)
• STOT SE 3 (96.2%)

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