Description

4-(4-Nitrophenyl)morpholin-3-one (CAS No. 446292-04-2) is a high-purity organic compound with the molecular formula C₁₀H₁₀N₂O₄. This nitrophenyl-substituted morpholinone derivative is a valuable intermediate in synthetic organic chemistry and pharmaceutical research. The compound features a morpholin-3-one core structure substituted at the 4-position with a 4-nitrophenyl group, offering unique electronic and steric properties for further functionalization.

Our product is synthesized under strict quality control measures to ensure >98% purity (HPLC), with full characterization by ¹H NMR, ¹³C NMR, and mass spectrometry. The compound is supplied as a crystalline solid with excellent batch-to-batch consistency, packaged under inert atmosphere to ensure long-term stability. Ideal for medicinal chemistry, heterocyclic compound synthesis, and as a building block for more complex nitrogen-containing structures.

Key Specifications:
– Molecular Weight: 222.20 g/mol
– Appearance: Yellow to light brown crystalline powder<br- Melting Point: 150-154°C (lit.)
– Storage: Store at 2-8°C in a tightly sealed container
– Hazard Information: Irritant (GHS07)

Properties

• CAS Number: 446292-04-2
• Complexity: 281
• IUPAC Name: 4-(4-nitrophenyl)morpholin-3-one
• InChI: InChI=1S/C10H10N2O4/c13-10-7-16-6-5-11(10)8-1-3-9(4-2-8)12(14)15/h1-4H,5-7H2
• InChI Key: OWMGEFWSGOTGAU-UHFFFAOYSA-N
• Exact Mass: 222.06405680
• Molecular Formula: C10H10N2O4
• Molecular Weight: 222.20
• SMILES: C1COCC(=O)N1C2=CC=C(C=C2)[N+](=O)[O-]
• Topological: 75.4
• Monoisotopic Mass: 222.06405680
• Synonyms: 4-(4-NITROPHENYL)-3-MORPHOLINONE, 4-(4-Nitrophenyl)-morpholin-3-ON, EC 610-199-1, 610-199-1, 4-(4-nitrophenyl)morpholin-3-one, 446292-04-2, 3-Morpholinone, 4-(4-nitrophenyl)-, 4-(4-nitrophenyl)-3-oxomorpholine, MFCD08236741, 4-(3-Oxo-4-morpholinyl)nitrobenzene, 3-Morpholinone,4-(4-nitrophenyl)-, 4-(4-Nitrophenyl)-3-morpholinone; 4-(3-Oxo-4-morpholinyl)nitrobenzene; 4-(4-Nitrophenyl)-3-oxomorpholine; 4-(4-Nitrophenyl)morpholin-3-one, YZ6LB5TLR9, SCHEMBL78624, DTXSID20466164, OWMGEFWSGOTGAU-UHFFFAOYSA-N, BCP05340, CS-B0475, 4-(4-Morpholin-3-onyl)nitrobenzene, 4-(4-Morpholin-3-onyl)-nitrobenzene, 4-(4-Nitro-phenyl)-morpholin-3-one, AKOS015833452, AB43897, GE-0240, AC-26442, SY066022, NS00002232, O11076

Application

4-(4-Nitrophenyl)morpholin-3-one serves as a versatile intermediate in pharmaceutical research, particularly in the development of kinase inhibitors and CNS-active compounds. The nitrophenyl group makes this compound valuable for subsequent reduction to aminophenyl derivatives, which are important pharmacophores. Researchers utilize this morpholinone derivative in heterocyclic chemistry to construct more complex nitrogen-containing scaffolds. The compound’s rigid structure also makes it useful for studying molecular interactions in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (25%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Acute Tox. 4 (25%)
• Acute Tox. 4 (25%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.