Description

4-(4-Aminophenoxy)-N-methylpicolinamide (CAS No. 284462-37-9) is a high-purity organic compound with the molecular formula C₁₃H₁₃N₃O₂ and IUPAC name 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide. This specialized chemical is designed for research and pharmaceutical applications, offering exceptional quality and consistency. Its unique structure, featuring an aminophenoxy group linked to a methylpicolinamide moiety, makes it a valuable intermediate in medicinal chemistry and drug discovery. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure ≥98% purity. Available in quantities from milligrams to kilograms, this compound is ideal for researchers requiring precise and reliable building blocks for heterocyclic synthesis.

Properties

• CAS Number: 284462-37-9
• Complexity: 277
• IUPAC Name: 4-(4-aminophenoxy)-N-methyl-pyridine-2-carboxamide
• InChI: InChI=1S/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)
• InChI Key: RXZZBPYPZLAEFC-UHFFFAOYSA-N
• Exact Mass: 243.100776666
• Molecular Formula: C13H13N3O2
• Molecular Weight: 243.26
• SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)N
• Topological: 77.2
• Monoisotopic Mass: 243.100776666
• Synonyms: 4-(4-Aminophenoxy)-N-methylpicolinamide, 284462-37-9, 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide, 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide, 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-, RE332HKD3U, DTXSID10586507, EC 608-211-5, DTXCID70537272, 608-211-5, [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide, 1178134-86-5, 4-(4-amino-phenoxy)-pyridine-2-carboxylic acid methylamide, MFCD08692047, 4-(4-amino-phenoxy)-pyridine-2-carboxylicacidmethylamide, UNII-RE332HKD3U, SCHEMBL177735, RXZZBPYPZLAEFC-UHFFFAOYSA-N, ALBB-015319, BCP04088, CS-D1788, AKOS005174935, AC-8441, FA17813, ND-0205, PB42455, SB31024, SY031392, A2617, NS00006940, 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline, EN300-146904, 4-(2-(N-methylcarbamoyl)-4-pyridyloxy) aniline, 4-(2-(N-methylcarbarnoyl)-4-pyridyloxy)aniline, N-methyl-4-(4-aminophenoxy)pyridine-2-carboxamide, 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide, 4-(4-amino-phenoxy)pyridine-2-carboxylic acid methylamide, 2-pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-, oxalate, 4-(4-aminophenoxy)-N-Methyl-2-pyridinecarboxamide, AldrichCPR, 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpicolinamide;4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]an iline

Application

4-(4-Aminophenoxy)-N-methylpicolinamide serves as a key intermediate in the synthesis of kinase inhibitors and other bioactive molecules. Researchers utilize this compound in medicinal chemistry projects targeting cancer therapeutics and signal transduction modulation. Its bifunctional structure allows for further derivatization at both the amino and amide groups, enabling diverse molecular scaffold development.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (16.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H341 (16.7%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H411 (33.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2 (66.7%)
• STOT SE 3 (16.7%)
• Muta. 2 (16.7%)
• Aquatic Chronic 2 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.