Description

{4-[1-Methyl-4-(trifluoromethyl)imidazol-2-yl]phenyl}methanol (CAS: 2446481-80-5) is a high-purity, specialty organic compound with the molecular formula C₁₂H₁₁F₃N₂O. This trifluoromethyl-substituted imidazole derivative features a benzyl alcohol functional group, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science research. The compound is supplied as a white to off-white crystalline solid with ≥95% purity (HPLC), rigorously characterized by ¹H NMR, ¹³C NMR, and LC-MS to ensure structural integrity. Optimal storage conditions are 2-8°C under inert atmosphere to maintain stability. Available in research quantities (100mg to 10g) with custom synthesis options.

Properties

• CAS Number: 2446481-80-5
• Complexity: 277
• IUPAC Name: [4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methanol
• InChI: InChI=1S/C12H11F3N2O/c1-17-6-10(12(13,14)15)16-11(17)9-4-2-8(7-18)3-5-9/h2-6,18H,7H2,1H3
• InChI Key: ATZWHYBBOBJZFI-UHFFFAOYSA-N
• Exact Mass: 256.08234746
• Molecular Formula: C12H11F3N2O
• Molecular Weight: 256.22
• SMILES: CN1C=C(N=C1C2=CC=C(C=C2)CO)C(F)(F)F
• Topological: 38.1
• Monoisotopic Mass: 256.08234746
• Synonyms: 2446481-80-5, {4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenyl}methanol, (4-(1-METHYL-4-(TRIFLUOROMETHYL)-1H-IMIDAZOL-2-YL)PHENYL)METHANOL, [4-[1-Methyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methanol, SCHEMBL22122030, ATZWHYBBOBJZFI-UHFFFAOYSA-N, DB-396194, G76738, 4-[1-Methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]benzenemethanol

Application

This compound serves as a key building block for developing novel trifluoromethyl-containing heterocycles in medicinal chemistry. Researchers utilize it as a precursor for kinase inhibitor development due to the privileged imidazole scaffold. The benzyl alcohol moiety enables facile derivatization through esterification or etherification reactions. In materials science, it finds application as a monomer for specialty polymers with enhanced thermal stability. The trifluoromethyl group imparts unique electronic properties valuable for agrochemical research.

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