Description

(3S)-oxolan-3-amine hydrochloride (CAS No. 204512-95-8) is a high-purity chiral amine derivative with the molecular formula C₄H₁₀ClNO. This compound is a hydrochloride salt of (S)-3-aminotetrahydrofuran, featuring a tetrahydrofuran ring with an amine group at the 3-position in the (S)-configuration. It is widely used in pharmaceutical research, asymmetric synthesis, and as a building block for bioactive molecules. The product is supplied as a white to off-white crystalline solid with ≥98% purity (HPLC), ensuring optimal performance in sensitive applications. Its stereochemical purity makes it invaluable for enantioselective reactions and drug discovery. Store under inert conditions at 2-8°C to maintain stability.

Properties

• CAS Number: 204512-95-8
• Complexity: 46.8
• IUPAC Name: (3S)-tetrahydrofuran-3-amine;hydrochloride
• InChI: InChI=1S/C4H9NO.ClH/c5-4-1-2-6-3-4;/h4H,1-3,5H2;1H/t4-;/m0./s1
• InChI Key: MHOVLDXJDIEEMJ-WCCKRBBISA-N
• Exact Mass: 123.0450916
• Molecular Formula: C4H10ClNO
• Molecular Weight: 123.58
• SMILES: C1COC[C@H]1N.Cl
• Topological: 35.3
• Monoisotopic Mass: 123.0450916
• Synonyms: (3S)-oxolan-3-amine hydrochloride, 3-Furanamine, tetrahydro-, hydrochloride (1:1), (3S)-, 663-078-0, 204512-95-8, (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE, (S)-3-aminotetrahydrofuran hydrochloride, (3s)-oxolan-3-amine;hydrochloride, (S)-Tetrahydro-furan-3-ylamine hydrochloride, (S)-TETRAHYDROFURAN-3-AMINE HCL, (S)-3-Aminotetrahydrofuran, HCl, MFCD08445642, (S)-3-aminotetrahydrofuran HCl, 3-Furanamine, tetrahydro-, hydrochloride, (3S)-, (S)-Tetrahydrofuran-3-Aminehydrochloride, (S)-tetrahydrofuran-3-ylamine hydrochloride, SCHEMBL286061, DTXSID30595393, (S)-tetrahydrofuran-3-amine-HCl, MHOVLDXJDIEEMJ-WCCKRBBISA-N, BCP06180, AKOS015849614, AKOS015899531, CS-W019697, DS-12044, FT142376, (3S)-Tetrahydro-3-furanamine hydrochloride, (s)-3-aminotetrahydrofuran hydrochloride salt, EN300-256935, (3S)-Oxolan-3-amine–hydrogen chloride (1/1), (S)-Tetrahydro-furan-3-ylamine hydrochloride, AldrichCPR

(3S)-oxolan-3-amine hydrochloride is a key chiral intermediate in the synthesis of pharmaceuticals and agrochemicals. It serves as a precursor for bioactive molecules, particularly in the development of enzyme inhibitors and receptor modulators. Researchers utilize this compound in asymmetric catalysis and peptidomimetic studies. Its rigid tetrahydrofuran scaffold is valuable for conformational restriction in drug design.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (95%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (95%)
• STOT SE 3 (100%)

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