Description

3,5-Difluorobenzyl chloride (CAS No. 220141-71-9) is a high-purity organic compound with the molecular formula C₇H₅ClF₂, widely utilized in pharmaceutical and agrochemical research. This versatile reagent serves as a critical intermediate in the synthesis of complex molecules due to its reactive chloromethyl and difluorophenyl functional groups. The compound is rigorously tested for quality, ensuring optimal performance in coupling reactions, nucleophilic substitutions, and as a precursor for advanced materials. Supplied as a clear to pale-yellow liquid, it is packaged under inert conditions to maintain stability and purity. Ideal for researchers requiring precise fluorinated building blocks, this product is available in various quantities to suit laboratory and industrial-scale applications.

Properties

• CAS Number: 220141-71-9
• Complexity: 97.8
• IUPAC Name: 1-(chloromethyl)-3,5-difluoro-benzene
• InChI: InChI=1S/C7H5ClF2/c8-4-5-1-6(9)3-7(10)2-5/h1-3H,4H2
• InChI Key: VNGSMSFVLAAOGK-UHFFFAOYSA-N
• Exact Mass: 162.0047842
• Molecular Formula: C7H5ClF2
• Molecular Weight: 162.56
• SMILES: C1=C(C=C(C=C1F)F)CCl
• Monoisotopic Mass: 162.0047842
• Synonyms: 3,5-Difluorobenzyl chloride, 220141-71-9, DTXSID30371730, DTXCID90322763, 1-(chloromethyl)-3,5-difluorobenzene, 3,5-DIFLUOROBENZYLCHLORIDE, BENZENE, 1-(CHLOROMETHYL)-3,5-DIFLUORO-, 1-chloromethyl-3,5-difluoro-benzene, MFCD01090990, SCHEMBL612513, SCHEMBL28840333, VNGSMSFVLAAOGK-UHFFFAOYSA-N, BBL100046, SBB087650, STL185674, 5-(chloromethyl)-1,3-difluorobenzene, AKOS005254298, AB08246, AS-38685, EN300-126073

Application

3,5-Difluorobenzyl chloride is extensively employed in medicinal chemistry for the synthesis of fluorinated drug candidates, leveraging its ability to introduce difluorobenzyl motifs. It serves as a key intermediate in the production of agrochemicals, particularly herbicides and pesticides, due to its stability and reactivity. Researchers also utilize this compound in material science for developing specialty polymers and liquid crystals with enhanced properties.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.