Description

3,5-Difluorobenzaldehyde (CAS No. 32085-88-4) is a high-purity fluorinated aromatic aldehyde with the molecular formula C₇H₄F₂O. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its structure features two fluorine atoms at the meta positions relative to the formyl group, enhancing its reactivity and utility in nucleophilic substitution reactions. The product is supplied as a clear to pale-yellow liquid or crystalline solid, with a purity of ≥97% (GC), ensuring consistency for sensitive applications. It is stored under inert conditions to maintain stability and is compatible with a wide range of reagents, including Grignard reagents and reducing agents. Ideal for use in Suzuki couplings, reductive amination, and as a precursor for heterocyclic compounds.

Properties

• CAS Number: 32085-88-4
• Complexity: 117
• IUPAC Name: 3,5-difluorobenzaldehyde
• InChI: InChI=1S/C7H4F2O/c8-6-1-5(4-10)2-7(9)3-6/h1-4H
• InChI Key: ASOFZHSTJHGQDT-UHFFFAOYSA-N
• Exact Mass: 142.02302107
• Molecular Formula: C7H4F2O
• Molecular Weight: 142.10
• SMILES: C1=C(C=C(C=C1F)F)C=O
• Topological: 17.1
• Monoisotopic Mass: 142.02302107
• Synonyms: 3,5-Difluorobenzaldehyde, 32085-88-4, ASOFZHSTJHGQDT-UHFFFAOYSA-, DTXSID30343199, DTXCID90294279, 608-701-9, asofzhstjhgqdt-uhfffaoysa-n, inchi=1/c7h4f2o/c8-6-1-5(4-10)2-7(9)3-6/h1-4h, MFCD00010329, 3,5-difluoro-benzaldehyde, BENZALDEHYDE, 3,5-DIFLUORO-, 3,5difluorobenzaldehyde, 3,5-diflourobenzaldehyde, 3, 5-difluorobenzaldehyde, SCHEMBL96268, SCHEMBL96269, (3,5-difluorophenyl)methanone, SCHEMBL15067670, SCHEMBL15067837, 3,5-Difluorobenzaldehyde, 98%, CS-D1127, SBB052160, STK510037, AKOS005255053, AB01034, AC-3836, PS-9010, DB-023890, A1633, D2626, NS00120214, ST50823769, EN300-50949, Z608082892

Application

3,5-Difluorobenzaldehyde is widely used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates. It serves as a key precursor in the preparation of antifungal, antiviral, and anticancer agents. In material science, it is employed to modify polymer properties or create fluorinated liquid crystals. Researchers also utilize it in the development of agrochemicals, such as herbicides and pesticides, due to its bioactivity-enhancing fluorine substituents.

Safety and Hazards

GHS Hazard Statements

• H226 (88%): Flammable liquid and vapor [Warning Flammable liquids]
• H228 (10%): Flammable solid [Danger Flammable solids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (96%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (88%)
• Flam. Sol. 2 (10%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (96%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.