Description

3,5-Difluoroaniline (CAS No. 372-39-4) is a high-purity aromatic amine derivative with the molecular formula C₆H₅F₂N. This compound features a benzene ring substituted with two fluorine atoms at the 3 and 5 positions and an amino group at the 1 position, offering unique reactivity for electrophilic substitution and coupling reactions. Ideal for pharmaceutical intermediates, agrochemical synthesis, and advanced material research, our 3,5-Difluoroaniline is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers to prevent degradation. Suitable for use in Suzuki-Miyaura cross-coupling, amidation, and other fine chemical processes, this reagent is a versatile building block for researchers and industrial chemists.

Properties

• CAS Number: 372-39-4
• Complexity: 87.1
• IUPAC Name: 3,5-difluoroaniline
• InChI: InChI=1S/C6H5F2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2
• InChI Key: KQOIBXZRCYFZSO-UHFFFAOYSA-N
• Exact Mass: 129.03900549
• Molecular Formula: C6H5F2N
• Molecular Weight: 129.11
• SMILES: C1=C(C=C(C=C1F)F)N
• Topological: 26
• Monoisotopic Mass: 129.03900549
• Physical Description: Other Solid
• Synonyms: 3,5-Difluoroaniline, 372-39-4, Benzenamine, 3,5-difluoro-, 3,5-Difluoro Aniline, 3,5-difluorophenylamine, 93F28C8C0X, EINECS 206-752-8, NSC-81289, UNII-93F28C8C0X, DTXSID0059906, KQOIBXZRCYFZSO-UHFFFAOYSA-, NSC 81289, DTXCID0039300, 206-752-8, inchi=1/c6h5f2n/c7-4-1-5(8)3-6(9)2-4/h1-3h,9h2, kqoibxzrcyfzso-uhfffaoysa-n, 3,5-Difluorobenzenamine, MFCD00007763, 3,5-difluoranilin, 3,5-difluoroanilin, 3,5 difluoroaniline, 3.5-difluoroaniline, 3, 5-difluoroaniline, 3,5-difluoro-aniline, 3,5-Difluoro-phenylamine, (3,5-difluorophenyl)amine, SCHEMBL69602, 3,5-Difluoroaniline, 98%, 5AN, SCHEMBL1776736, SCHEMBL2232172, SCHEMBL26185856, CS-D1125, NSC81289, SBB028234, STL169017, AKOS001407524, DB03238, PS-9153, SB75374, SDCCGMLS-0066233.P001, AC-10342, BP-11914, PD007310, D2665, NS00042188, EN300-23894, Q27094167, F0001-1071, Z166631028

Application

3,5-Difluoroaniline is widely employed as a key intermediate in the synthesis of pharmaceuticals, including active pharmaceutical ingredients (APIs) and bioactive molecules. It serves as a precursor for agrochemicals such as herbicides and fungicides due to its fluorine-enhanced reactivity. Additionally, this compound is utilized in material science for the development of liquid crystals, dyes, and specialty polymers. Its electron-withdrawing fluorine substituents make it valuable in palladium-catalyzed cross-coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (99.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (28.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (73.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (73.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (28.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (99.3%)
• Acute Tox. 4 (28.8%)
• Skin Irrit. 2 (73.9%)
• Eye Irrit. 2 (73.9%)
• Acute Tox. 4 (28.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.