Description

3,5-Dichloropyridin-4-amine (CAS No. 22889-78-7) is a high-purity chlorinated pyridine derivative with the molecular formula C₅H₄Cl₂N₂. This compound is an essential building block in pharmaceutical and agrochemical synthesis, featuring a reactive amino group and two chlorine substituents on the pyridine ring for selective functionalization. Its crystalline form ensures consistent reactivity, making it ideal for nucleophilic substitution, cross-coupling, and heterocycle elaboration. Packaged under inert conditions to maintain stability, this product is rigorously tested via HPLC, GC, and NMR to guarantee ≥98% purity. Suitable for research-scale and process development applications.

Properties

• CAS Number: 22889-78-7
• Complexity: 89
• IUPAC Name: 3,5-dichloropyridin-4-amine
• InChI: InChI=1S/C5H4Cl2N2/c6-3-1-9-2-4(7)5(3)8/h1-2H,(H2,8,9)
• InChI Key: ISIQAMHROGZHOV-UHFFFAOYSA-N
• Exact Mass: 161.9751535
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.00
• SMILES: C1=C(C(=C(C=N1)Cl)N)Cl
• Topological: 38.9
• Monoisotopic Mass: 161.9751535
• Synonyms: 4-Amino-3,5-dichloropyridine, 22889-78-7, 3,5-Dichloropyridin-4-amine, 4-Pyridinamine, 3,5-dichloro-, F7AS459SFD, EINECS 245-304-6, DTXSID00177428, ROFLUMILAST METABOLITE M10, BYK20139, 4-ADCP, DTXCID3099919, 245-304-6, 3,5-dichloro-4-aminopyridine, 228809-78-7, 3,5-Dichloro-4-pyridinamine, MFCD00125023, 3,5-Dichloro-4-pyridine amine, 3,5-dichloro-4-amino pyridine, 4-amino-3,5-dichloro pyridine, EN300-17307, 3,5-dichloro-4-pyridylamine, 3,5-Dichloro-4-aminopyridine; 3,5-Dichloropyridin-4-ylamine;, Maybridge1_006016, UNII-F7AS459SFD, 4-amino3,5-dichloropyridine, SCHEMBL71151, AC-907/25014344, 3,5 dichloro-4-aminopyridine, 3,5-dichloropyridine-4-amine, 3,5dichloro-4-amino pyridine, 3,5-dichloropyridin-4-ylamine, F3284-6482, SCHEMBL1531048, SCHEMBL3543193, 3,5-dichloro 4-amino pyridine, 4-amino 3,5-dichloro pyridine, 4-amino-3,5-dichloro-pyridine, 3,5-Dichloro-4-pyridinamine #, 3,5-dichloro-pyridin-4-ylamine, HMS558J10, BDBM626048, Pyridin-4-amino, 3,5-dichloro-, BCP22965, CS-D1725, STR09436, SBB016175, STL227728, AKOS000267402, AB03509, AC-4663, FA16332, SY014938, 4-Amino-3,5-dichloropyridine, AldrichCPR, DB-028688, A1545, NS00027288, ST45174683, Z56914860, Y2C

Application

3,5-Dichloropyridin-4-amine serves as a key intermediate in the synthesis of bioactive molecules, including herbicides and antiviral agents. Its dichloropyridine core is leveraged in Suzuki-Miyaura couplings to construct complex heterocycles. Researchers also utilize it to develop ligands for catalytic systems or as a precursor for functionalized pyridine scaffolds in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H300 (47.9%): Fatal if swallowed [Danger Acute toxicity, oral]
• H302 (21.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H310 (47.9%): Fatal in contact with skin [Danger Acute toxicity, dermal]
• H315 (99.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (66.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (33.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H330 (47.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]
• H335 (99.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 1 (47.9%)
• Acute Tox. 4 (21.5%)
• Acute Tox. 1 (47.9%)
• Skin Irrit. 2 (99.5%)
• Eye Dam. 1 (66.2%)
• Eye Irrit. 2A (33.3%)
• Acute Tox. 2 (47.9%)
• STOT SE 3 (99.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.