Description

3,5-Dichloro-3-pyridylamine (CAS No. 4214-74-8) is a high-purity heterocyclic organic compound with the molecular formula C₅H₄Cl₂N₂. This fine chemical, also known by its IUPAC name 3,5-dichloropyridin-2-amine, is a valuable intermediate in pharmaceutical and agrochemical synthesis. The compound features a pyridine ring substituted with two chlorine atoms at the 3 and 5 positions and an amine group at the 2 position, offering versatile reactivity for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder under inert packaging to maintain stability. Suitable for research and development in medicinal chemistry, this compound is packaged in amber glass vials or bulk quantities with comprehensive analytical data (MSDS, NMR, HPLC) available upon request.

Properties

• CAS Number: 4214-74-8
• Complexity: 99
• IUPAC Name: 3,5-dichloropyridin-2-amine
• InChI: InChI=1S/C5H4Cl2N2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)
• InChI Key: OCWBGKZFOYMCCN-UHFFFAOYSA-N
• Exact Mass: 161.9751535
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.00
• SMILES: C1=C(C=NC(=C1Cl)N)Cl
• Topological: 38.9
• Monoisotopic Mass: 161.9751535
• Synonyms: 2-Amino-3,5-dichloropyridine, 4214-74-8, 3,5-Dichloro-3-pyridylamine, EINECS 224-143-5, DTXSID80194976, NSC 51586, DTXCID20117467, 224-143-5, inchi=1/c5h4cl2n2/c6-3-1-4(7)5(8)9-2-3/h1-2h,(h2,8,9, 3,5-dichloropyridin-2-amine, 3,5-Dichloro-2-pyridinamine, MFCD00006313, 2-Pyridinamine, 3,5-dichloro-, 3,5-Dichloro-2-aminopyridine, Pyridine, 2-amino-3,5-dichloro-, 3,5-dichloro-2-pyridylamine, NSC51586, 3,5 dichloro-aminopyridine, 2-Pyridinamine,5-dichloro-, SCHEMBL120637, SCHEMBL885353, 2-Amino-3.5-dichloropyridine, 3,5-dichloropyridin-2-ylamine, SCHEMBL1427660, 3,5-Dichloro-2-amino pyridine, SCHEMBL11548541, 3,5-dichloro-pyridin-2-ylamine, ALBB-016362, STR03540, NSC-51586, RB1110, SBB003932, STK510042, 2-Amino-3,5-dichloropyridine, 97%, AKOS000120497, AB00689, AC-6261, FA07003, PS-5112, BP-12779, SY013758, DB-000449, A1502, CS-0022292, NS00031109, ST50211869, EN300-20161, AC-907/25014045, Z104477096

Application

3,5-Dichloro-3-pyridylamine serves as a key building block in the synthesis of advanced pharmaceutical compounds, particularly in the development of kinase inhibitors and antimicrobial agents. It is widely utilized in agrochemical research for creating novel pesticides and herbicides due to its bioactive pyridine core. The compound’s reactive sites enable facile functionalization for structure-activity relationship (SAR) studies in drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302 (14.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.9%)
• Acute Tox. 4 (12.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (12.8%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.