Description

3,4,5-Trifluorobenzenesulfonyl chloride (CAS No. 351003-43-5) is a high-purity organosulfur compound with the molecular formula C₆H₂ClF₃O₂S. This specialized reagent features a benzenesulfonyl chloride core substituted with three fluorine atoms at the 3, 4, and 5 positions, enhancing its reactivity in nucleophilic substitution and coupling reactions. Ideal for pharmaceutical intermediates, agrochemical synthesis, and material science applications, this compound is rigorously tested for consistency and purity (typically ≥95% by HPLC or GC analysis). Packaged under inert gas to ensure stability, it is available in quantities ranging from grams to kilograms with customizable packaging options. Store in a cool, dry place away from moisture and incompatible substances.

Properties

• CAS Number: 351003-43-5
• Complexity: 264
• IUPAC Name: 3,4,5-trifluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H2ClF3O2S/c7-13(11,12)3-1-4(8)6(10)5(9)2-3/h1-2H
• InChI Key: HSEHKULCGSMHAE-UHFFFAOYSA-N
• Exact Mass: 229.9416127
• Molecular Formula: C6H2ClF3O2S
• Molecular Weight: 230.59
• SMILES: C1=C(C=C(C(=C1F)F)F)S(=O)(=O)Cl
• Topological: 42.5
• Monoisotopic Mass: 229.9416127
• Synonyms: 3,4,5-Trifluorobenzenesulfonyl chloride, 351003-43-5, DTXSID40381163, DTXCID70332188, 624-447-1, 3,4,5-Trifluorobenzene-1-sulfonyl chloride, MFCD03094559, 3,4,5-trifluorobenzenesulfonylchloride, Benzenesulfonyl chloride, 3,4,5-trifluoro-, SCHEMBL282282, BBL100708, CK1138, SBB097648, STL554502, chloro(3,4,5-trifluorophenyl)sulfone, AKOS005254991, DS-14879, SY075115, 3,4,5-Trifluorobenzene-1-sulfonylchloride, DB-069135, CS-0127976, EN300-85294

Application

3,4,5-Trifluorobenzenesulfonyl chloride serves as a key building block in the synthesis of sulfonamide derivatives for drug discovery, particularly in antimicrobial and anticancer agents. Its electron-withdrawing trifluoromethyl groups enhance reactivity in Suzuki-Miyaura cross-coupling reactions for advanced material development. Researchers also utilize it in proteomics studies as a labeling reagent for peptide modification.

Safety and Hazards

GHS Hazard Statements

• H226 (87.2%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (87.2%)
• Skin Corr. 1B (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.