Atomfair 3,4,5-Trifluorobenzaldehyde C7H3F3O CAS 132123-54-7

Description

3,4,5-Trifluorobenzaldehyde (CAS No. 132123-54-7) is a high-purity fluorinated aromatic aldehyde with the molecular formula C₇H₃F₃O. This compound is a versatile building block in organic synthesis, particularly for pharmaceuticals, agrochemicals, and advanced materials research. Its trifluorinated benzene ring enhances electron-withdrawing properties, making it valuable for modifying reactivity in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic compounds. Available at 97% purity, this reagent is rigorously tested for consistency and stability, ensuring reliable performance in sensitive applications. Suitable for use under inert conditions due to its sensitivity to oxidation. Packaged in amber glass vials to protect against light degradation.

Properties

• CAS Number: 132123-54-7
• Complexity: 139
• IUPAC Name: 3,4,5-trifluorobenzaldehyde
• InChI: InChI=1S/C7H3F3O/c8-5-1-4(3-11)2-6(9)7(5)10/h1-3H
• InChI Key: NLAVHUUABUFSIG-UHFFFAOYSA-N
• Exact Mass: 160.01359920
• Molecular Formula: C7H3F3O
• Molecular Weight: 160.09
• SMILES: C1=C(C=C(C(=C1F)F)F)C=O
• Topological: 17.1
• Monoisotopic Mass: 160.01359920
• Synonyms: 3,4,5-Trifluorobenzaldehyde, 132123-54-7, DTXSID90380308, DTXCID30331334, 603-550-5, Benzaldehyde, 3,4,5-trifluoro-, MFCD00083523, 3,4,5-Trifluoro-benzaldehyde, 3,4,5-triflourobenzaldehyde, SCHEMBL48658, 3,4,5-trifluoro benzaldehyde, SCHEMBL2550076, 3,4,5-Trifluorobenzaldehyde, 97%, BBL028174, CL8293, SBB063856, STL374068, AKOS004911140, AC-3862, CS-W017942, FT64093, PS-10189, SY022934, DB-023720, NS00123782, ST50824763, T2321, EN300-67516, Z1080487078

3,4,5-Trifluorobenzaldehyde is widely used as a key intermediate in the synthesis of pharmaceutical candidates, especially for fluorinated drug molecules targeting CNS disorders and antimicrobial agents. Its electron-deficient aromatic ring facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings. Researchers also employ it in material science to develop liquid crystals and OLED components. Handle under nitrogen/argon to prevent aldehyde oxidation.

Safety and Hazards

GHS Hazard Statements

• H301 (83.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (83.3%)
• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2A (97.9%)
• STOT SE 3 (95.8%)

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