Description

3,4,5-Tribromopyridine (CAS No. 2457-48-9) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂Br₃N. This compound is characterized by its three bromine substituents at the 3, 4, and 5 positions of the pyridine ring, offering unique reactivity for advanced synthetic applications. With a molecular weight of 315.79 g/mol, it is a white to off-white crystalline solid with excellent stability under standard conditions. Ideal for researchers in pharmaceutical, agrochemical, and materials science, this product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed, light-resistant packaging to maintain integrity. Suitable for use as a versatile building block in cross-coupling reactions, nucleophilic substitutions, and as a precursor for complex heterocyclic systems.

Properties

• CAS Number: 2457-48-9
• Complexity: 88.2
• IUPAC Name: 3,4,5-tribromopyridine
• InChI: InChI=1S/C5H2Br3N/c6-3-1-9-2-4(7)5(3)8/h1-2H
• InChI Key: CWYVUHWKGWQPLP-UHFFFAOYSA-N
• Exact Mass: 314.77169
• Molecular Formula: C5H2Br3N
• Molecular Weight: 315.79
• SMILES: C1=C(C(=C(C=N1)Br)Br)Br
• Topological: 12.9
• Monoisotopic Mass: 312.77374
• Synonyms: 3,4,5-Tribromopyridine, 2457-48-9, DTXSID90337276, DTXCID80288364, 641-239-6, Pyridine, 3,4,5-tribromo-, MFCD01646053, SCHEMBL526296, SCHEMBL9480252, 3,4,5-Tribromopyridine, 97%, CWYVUHWKGWQPLP-UHFFFAOYSA-N, AKOS005258039, AS-75725, SY052980, DB-017655, CS-0195773, T3248, I10241, AC-907/30002030

Application

3,4,5-Tribromopyridine serves as a key intermediate in the synthesis of brominated pharmaceuticals and ligands for catalysis. It is widely utilized in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to construct biaryl systems. Additionally, this compound finds application in the development of flame retardants and functional materials due to its high bromine content. Researchers also employ it in the preparation of pyridine-based metal-organic frameworks (MOFs) and as a substrate for selective functionalization studies.

Safety and Hazards

GHS Hazard Statements

• H301 (88.9%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (88.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (88.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (95.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (88.9%)
• Acute Tox. 3 (88.9%)
• Skin Irrit. 2 (97.8%)
• Eye Irrit. 2 (97.8%)
• Acute Tox. 3 (88.9%)
• STOT SE 3 (95.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.