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Atomfair 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- [‘Galidesivir hydrochloride’, ‘BCX 4430’, ‘BCX 4430 Hydrochloride’] C11H16ClN5O3 CAS 222631-44-9

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- (CAS No. 222631-44-9), also known as Galidesivir Hydrochloride or BCX 4430 Hydrochloride, is a high-purity synthetic nucleoside analogue with a molecular formula of C11H16ClN5O3. This compound is a hydrochloride salt form of Galidesivir, exhibiting potent antiviral activity against a broad spectrum of RNA viruses, including filoviruses and flaviviruses. Its stereospecific structure ((2S,3S,4R,5R)-configuration) ensures optimal binding to viral polymerases, making it a valuable tool for antiviral research. Ideal for pharmaceutical development and biochemical studies, this product is rigorously tested for purity (>98% by HPLC) and stability, supplied as a lyophilized powder or in solution for ease of…

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Description

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- (CAS No. 222631-44-9), also known as Galidesivir Hydrochloride or BCX 4430 Hydrochloride, is a high-purity synthetic nucleoside analogue with a molecular formula of C11H16ClN5O3. This compound is a hydrochloride salt form of Galidesivir, exhibiting potent antiviral activity against a broad spectrum of RNA viruses, including filoviruses and flaviviruses. Its stereospecific structure ((2S,3S,4R,5R)-configuration) ensures optimal binding to viral polymerases, making it a valuable tool for antiviral research. Ideal for pharmaceutical development and biochemical studies, this product is rigorously tested for purity (>98% by HPLC) and stability, supplied as a lyophilized powder or in solution for ease of use. Store at -20°C under inert conditions to maintain integrity.

Properties

  • CAS Number: 222631-44-9
  • Complexity: 333
  • IUPAC Name: (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride
  • InChI: InChI=1S/C11H15N5O3.ClH/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7;/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15);1H/t5-,7+,9-,10+;/m1./s1
  • InChI Key: PCCHVYNGFMEGIG-QPAIBFMUSA-N
  • Exact Mass: 301.0941671
  • Molecular Formula: C11H16ClN5O3
  • Molecular Weight: 301.73
  • SMILES: C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O.Cl
  • Topological: 140
  • Monoisotopic Mass: 301.0941671
  • Synonyms: 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-, 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-, 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-, 222631-44-9, Galidesivir hydrochloride, BCX 4430, BCX 4430 Hydrochloride, Galidesivir (hydrochloride), 1EL1K52SH1, (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride, Bcx-4430 hydrochloride, SCHEMBL4838048, PCCHVYNGFMEGIG-QPAIBFMUSA-N, DTXSID001028039, AKOS030526727, AT32549, CS-3778, NB58350, 2-(4-Amino-5H-pyrrolo(3,2-d)pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, DA-61549, HY-18649, MS-24349, (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride, (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;Galidesivir, 3,4-PYRROLIDINEDIOL, 2-(4-AMINO-5H-PYRROLO(3,2-D)PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-, HYDROCHLORIDE (1:1), (2S,3S,4R,5R)-

Galidesivir Hydrochloride is primarily used in antiviral research, particularly for studying RNA virus inhibition mechanisms. It has shown efficacy against Ebola, Marburg, and Zika viruses in preclinical models. The compound acts as a chain-terminating nucleotide analogue, disrupting viral replication. Researchers utilize it in in vitro and in vivo studies to explore therapeutic potential. Its hydrochloride form enhances solubility for experimental applications.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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