Description

[(3,4-Difluorophenyl)methyl](methyl)amine (CAS No. 748124-46-1) is a high-purity fluorinated aromatic amine with the molecular formula C₈H₉F₂N. This compound, also known as 1-(3,4-difluorophenyl)-N-methylmethanamine, is a valuable intermediate in pharmaceutical and agrochemical research. Its unique structure, featuring a difluorinated phenyl ring and a methylamine moiety, makes it an essential building block for the synthesis of bioactive molecules. Suitable for use in medicinal chemistry, drug discovery, and material science applications, this reagent is rigorously tested to ensure superior quality and consistency. Available in various quantities to meet both laboratory and industrial-scale demands.

Properties

• CAS Number: 748124-46-1
• Complexity: 119
• IUPAC Name: 1-(3,4-difluorophenyl)-N-methyl-methanamine
• InChI: InChI=1S/C8H9F2N/c1-11-5-6-2-3-7(9)8(10)4-6/h2-4,11H,5H2,1H3
• InChI Key: MMNUIVWEFIBTRB-UHFFFAOYSA-N
• Exact Mass: 157.07030562
• Molecular Formula: C8H9F2N
• Molecular Weight: 157.16
• SMILES: CNCC1=CC(=C(C=C1)F)F
• Topological: 12
• Monoisotopic Mass: 157.07030562
• Synonyms: 3,4-difluoro-n-methylbenzenemethanamine, [(3,4-difluorophenyl)methyl](methyl)amine, ((3,4-difluorophenyl)methyl)(methyl)amine, 874-291-5, 748124-46-1, 1-(3,4-difluorophenyl)-N-methylmethanamine, Benzenemethanamine,3,4-difluoro-N-methyl-, 3,4-Difluoro-N-methyl-benzylamine, N-(3,4-difluorobenzyl)-N-methylamine, SCHEMBL1585868, SCHEMBL2091788, SCHEMBL3483224, SCHEMBL20487718, DTXSID90588185, MFCD09043718, AKOS000127893, BS-13431, DB-347793, CS-0245380, EN300-30409, N12835, Z102767736

Application

[(3,4-Difluorophenyl)methyl](methyl)amine is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of CNS-active compounds and enzyme inhibitors. Its fluorinated aromatic structure enhances metabolic stability and bioavailability, making it valuable in drug discovery. Researchers also employ this compound in the design of agrochemicals and specialty materials. Its reactivity allows for further functionalization, enabling the creation of diverse derivatives for biological screening.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (100%)
• Eye Dam. 1 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.