Description

3,4-Difluorobenzene-1-sulfonyl chloride (CAS No. 145758-05-0) is a high-purity sulfonyl chloride derivative with the molecular formula C₆H₃ClF₂O₂S. This organofluorine compound is widely used as a key intermediate in pharmaceutical synthesis, agrochemical production, and advanced material research. The presence of both fluorine atoms and the reactive sulfonyl chloride group makes it a versatile building block for nucleophilic substitution reactions and cross-coupling chemistry.

Our product is synthesized under strict quality control measures to ensure >98% purity (HPLC) and is supplied as a moisture-sensitive, crystalline solid. Special packaging options (sealed ampoules or under inert gas) are available upon request to prevent hydrolysis. Technical specifications include:

• Molecular Weight: 212.60 g/mol
• Melting Point: 32-36°C
• Boiling Point: 265-267°C (with decomposition)
• Density: 1.52 g/cm³

Ideal for researchers developing novel sulfonamide drugs, fluorinated liquid crystals, or specialty polymers. MSDS and NMR spectra provided with every shipment.

Properties

• CAS Number: 145758-05-0
• Complexity: 249
• IUPAC Name: 3,4-difluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H3ClF2O2S/c7-12(10,11)4-1-2-5(8)6(9)3-4/h1-3H
• InChI Key: FSGLUBQENACWCC-UHFFFAOYSA-N
• Exact Mass: 211.9510345
• Molecular Formula: C6H3ClF2O2S
• Molecular Weight: 212.60
• SMILES: C1=CC(=C(C=C1S(=O)(=O)Cl)F)F
• Topological: 42.5
• Monoisotopic Mass: 211.9510345
• Synonyms: 3,4-Difluorobenzene-1-Sulfonyl Chloride, 626-645-3, 3,4-Difluorobenzenesulfonyl chloride, 145758-05-0, 3,4-Difluorobenzenesulphonyl chloride, Benzenesulfonyl chloride, 3,4-difluoro-, 3,4-difluoro-benzenesulfonyl chloride, 3,4-Difluorobenzenesulfonylchloride, 3,4-difluorobenzene sulfonyl chloride, (3,4-difluorophenyl)chlorosulfone, MFCD00153120, SCHEMBL68413, DTXSID30371699, 3,4-difluorophenylsulfonylchloride, 3,4-difluorobenzensulfonyl chloride, ALBB-000990, 3,4-difluorobenzene sulfonylchloride, BBL013794, SBB066467, STK500490, 3,4-di-fluorophenyl sulfonyl chloride, AKOS000309917, CS-W014270, 3,4-Difluorobenzene-1-SulfonylChloride, AS-18791, 3,4-Difluorobenzenesulfonyl chloride, 97%, DB-010048, D2941, EN300-01909, F1967-0686, Z104480384

Application

3,4-Difluorobenzene-1-sulfonyl chloride serves as a critical precursor in medicinal chemistry for constructing biologically active sulfonamides through reactions with amines. The electron-withdrawing fluorine substituents enhance the reactivity of the sulfonyl chloride group in nucleophilic aromatic substitutions. This compound finds particular utility in synthesizing protease inhibitors and kinase-targeted therapeutics. Industrial applications include the production of fluorinated surfactants and electrolyte additives for lithium-ion batteries.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (83.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Eye Dam. 1 (83.3%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.