Description

3,4-Difluorobenzaldehyde (CAS No. 34036-07-2) is a high-purity fluorinated aromatic aldehyde with the molecular formula C₇H₄F₂O. This versatile organic compound is widely used as a key intermediate in pharmaceutical synthesis, agrochemical production, and advanced material research. The presence of fluorine atoms at the 3- and 4-positions enhances its reactivity and makes it valuable for nucleophilic substitution reactions and cross-coupling chemistry. Our product is supplied with a guaranteed purity of ≥97%, rigorously tested via GC/HPLC and NMR to ensure batch-to-batch consistency. Ideal for Suzuki-Miyaura couplings, Grignard reactions, and as a precursor for liquid crystal materials. Available in secure amber glass vials or bulk quantities with customizable packaging under inert atmosphere.

Key Specifications:
• Molecular Weight: 142.10 g/mol
• Melting Point: ~30-34°C
• Boiling Point: ~195-198°C
• Density: 1.28 g/cm³
• Storage: 2-8°C under nitrogen
• Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 34036-07-2
• Complexity: 127
• IUPAC Name: 3,4-difluorobenzaldehyde
• InChI: InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)3-7(6)9/h1-4H
• InChI Key: JPHKMYXKNKLNDF-UHFFFAOYSA-N
• Exact Mass: 142.02302107
• Molecular Formula: C7H4F2O
• Molecular Weight: 142.10
• SMILES: C1=CC(=C(C=C1C=O)F)F
• Topological: 17.1
• Monoisotopic Mass: 142.02302107
• Synonyms: 3,4-Difluorobenzaldehyde, 34036-07-2, DTXSID00343186, DTXCID60294266, 422-180-3, 608-940-9, MFCD00010328, 3,4-difluoro-benzaldehyde, Benzaldehyde, 3,4-difluoro-, 3,4 difluorobenzaldehyde, 3,4-diflourobenzaldehyde, 3,4-difluoro-benzaldehye, 3,4-difluro-benzaldehyde, 3, 4-difluorobenzaldehyde, 3,4-difluoro benzaldehyde, 3,4-difluorobenz-aldehyde, 3,4-di-fluoro-benzaldehyde, SCHEMBL48607, SCHEMBL97003, SCHEMBL15066870, SCHEMBL15067134, SCHEMBL15067879, 3,4-Difluorobenzaldehyde, 97%, SBB063182, AKOS000120438, AC-3835, CS-W008607, PS-9014, SY001586, DB-023907, D2340, NS00122610, ST50823766, EN300-20340, doi:10.14272/JPHKMYXKNKLNDF-UHFFFAOYSA-N.1, F2190-0603, Z104477800, InChI=1/C7H4F2O/c8-6-2-1-5(4-10)3-7(6)9/h1-4

3,4-Difluorobenzaldehyde serves as a critical building block in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly kinase inhibitors and CNS-active compounds. Its electron-withdrawing fluorine substituents facilitate palladium-catalyzed cross-couplings in material science applications, including OLED and liquid crystal development. The compound is also employed in crop protection research for creating novel fungicides with enhanced metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (33.3%)
• Acute Tox. 4 (66.7%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (33.3%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (33.3%)
• Aquatic Chronic 3 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.