Description

3,3,4,4,5,5-Hexafluorodihydro-2H-pyran-2,6(3H)-dione (CAS No. 376-68-1) is a highly fluorinated cyclic anhydride with the molecular formula C₅F₆O₃. This specialized chemical compound, also known as Hexafluoroglutaric anhydride, is characterized by its unique hexafluorinated structure, which imparts exceptional reactivity and stability under demanding conditions. It is widely utilized in advanced organic synthesis, particularly in the preparation of fluorinated polymers, pharmaceuticals, and agrochemical intermediates. The compound’s high purity and consistent quality make it an indispensable reagent for researchers and industrial chemists working in fluorination chemistry and material science applications.

Available in various packaging options to suit laboratory and bulk-scale requirements, this product is handled under strict quality control measures to ensure optimal performance. Store in a cool, dry place, away from moisture and incompatible substances. For research use only.

Properties

• CAS Number: 376-68-1
• Complexity: 281
• IUPAC Name: 3,3,4,4,5,5-hexafluorotetrahydropyran-2,6-dione
• InChI: InChI=1S/C5F6O3/c6-3(7)1(12)14-2(13)4(8,9)5(3,10)11
• InChI Key: IHYAGCYJVNHXCT-UHFFFAOYSA-N
• Exact Mass: 221.97516283
• Molecular Formula: C5F6O3
• Molecular Weight: 222.04
• SMILES: C1(=O)C(C(C(C(=O)O1)(F)F)(F)F)(F)F
• Topological: 43.4
• Monoisotopic Mass: 221.97516283
• Physical Description: Colorless liquid with a pungent odor;
• Synonyms: Hexafluoroglutaric anhydride, 376-68-1, 3,3,4,4,5,5-Hexafluorodihydro-2H-pyran-2,6(3H)-dione, EINECS 206-811-8, 3,3,4,4,5,5Hexafluorodihydro2Hpyran2,6(3H)dione, 206-811-8, Perfluoroglutaric anhydride, 2,2,3,3,4,4-Hexafluoropentanedioic Anhydride, 3,3,4,4,5,5-hexafluorooxane-2,6-dione, C5F6O3, Hexafluoroglutaric acid anhydride, hexafluorooxane-2,6-dione, 3,3,4,4,5,5-hexafluoro-3H-4,5-dihydropyran-2,6-dione, MFCD00006680, CAZ3ABV3LS, SCHEMBL316973, DTXSID90191037, Hexafluoroglutaric anhydride, 97%, SBB096233, AKOS009099982, AT23280, PS-10626, DB-049162, H0745, NS00019032, ST51038135, EN300-25323, 2H-Pyran-2,6(3H)-dione, 3,3,4,4,5,5-hexafluorodihydro-, 2 pound not2 pound not3 pound not3 pound not4 pound not4-Hexafluoropentanedioic Anhydride, Perfluoroglutaric anhydride, 3,3,4,4,5,5-Hexafluorodihydro-2H-pyran-2,6(3H)-dione

Application

3,3,4,4,5,5-Hexafluorodihydro-2H-pyran-2,6(3H)-dione is primarily employed as a key intermediate in the synthesis of fluorinated polymers and specialty materials. Its reactivity as an anhydride makes it valuable for introducing hexafluorinated moieties into target molecules, enhancing their thermal and chemical resistance. Researchers also utilize this compound in the development of advanced pharmaceutical candidates and agrochemicals, where fluorination is critical for bioactivity. Additionally, it serves as a precursor in the preparation of fluorinated surfactants and coatings with unique hydrophobic properties.

Safety and Hazards

GHS Hazard Statements

• H314 (15.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (84.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (84.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (84.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (15.2%)
• Skin Irrit. 2 (84.8%)
• Eye Irrit. 2 (84.8%)
• STOT SE 3 (84.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.