Description

3,3,3-Trifluoro-1-propanol (CAS No. 2240-88-2) is a high-purity fluorinated alcohol with the molecular formula C₃H₅F₃O. This compound, also known by its IUPAC name 3,3,3-trifluoropropan-1-ol, is a versatile intermediate in organic synthesis and material science. It features a trifluoromethyl group attached to a short alkyl chain, offering unique physicochemical properties such as enhanced lipophilicity and metabolic stability. Suitable for use in pharmaceuticals, agrochemicals, and specialty chemicals, this product is rigorously tested for purity and consistency. Packaged under inert conditions to ensure stability, it is ideal for researchers requiring reliable fluorinated building blocks.

Properties

• CAS Number: 2240-88-2
• Complexity: 48.6
• IUPAC Name: 3,3,3-trifluoropropan-1-ol
• InChI: InChI=1S/C3H5F3O/c4-3(5,6)1-2-7/h7H,1-2H2
• InChI Key: HDBGBTNNPRCVND-UHFFFAOYSA-N
• Exact Mass: 114.02924926
• Molecular Formula: C3H5F3O
• Molecular Weight: 114.07
• SMILES: C(CO)C(F)(F)F
• Topological: 20.2
• Monoisotopic Mass: 114.02924926
• Synonyms: 3,3,3-Trifluoro-1-propanol, 3,3,3-Trifluoropropan-1-ol, DTXSID30870950, DTXCID00818627, 670-540-5, hdbgbtnnprcvnd-uhfffaoysa-n, 2240-88-2, 3,3,3-trifluoropropanol, 65530-60-1, MFCD00190649, 1-Propanol, 3,3,3-trifluoro-, trifluoropropanol, Fluorotelomer alcohol 1:2, SCHEMBL10126, SCHEMBL10127, FT-OH; C3H5F3O, SCHEMBL2276579, SCHEMBL3118013, SCHEMBL3521503, 3,3,3-Trifluoro-propan-1-ol, CHEMBL4515005, LBGHBSIAPDTBDS-UHFFFAOYSA-N, OMKIPPNZHKOTAO-UHFFFAOYSA-N, BBL103865, STL557675, AKOS005063409, AB04522, CS-W011251, FS-4379, FT78258, 3,3,3-trifluoro-1-propanol, AldrichCPR, DB-001241, NS00112281, T2986, EN300-70258, 3,3,3-Trifluoropropan-1-ol/toluene azeotropic mixture (~60:40)

Application

3,3,3-Trifluoro-1-propanol is widely used as a fluorinated synthon in pharmaceutical and agrochemical research. Its trifluoromethyl group enhances the bioavailability and metabolic resistance of target molecules. This compound is also employed in the synthesis of liquid crystals and specialty polymers due to its unique polarity and thermal stability. Additionally, it serves as a solvent or co-solvent in reactions requiring fluorinated media.

Safety and Hazards

GHS Hazard Statements

• H226 (23.5%): Flammable liquid and vapor [Warning Flammable liquids]
• H301 (76.5%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (96.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (23.5%)
• Acute Tox. 3 (76.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (96.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.