Description

3-(Trifluoromethyl)benzylic alcohol (CAS No. 349-75-7) is a high-purity fluorinated aromatic alcohol with the molecular formula C₈H₇F₃O and IUPAC name [3-(trifluoromethyl)phenyl]methanol. This compound features a benzyl alcohol moiety substituted with a trifluoromethyl group at the meta position, enhancing its electron-withdrawing properties and chemical reactivity. Ideal for pharmaceutical intermediates, agrochemical synthesis, and advanced material research, it is supplied as a clear, colorless to pale-yellow liquid with ≥98% purity (GC). Store under inert conditions at 2-8°C to ensure stability. Suitable for nucleophilic substitutions, esterifications, and cross-coupling reactions. Available in quantities from 1g to 1kg with optional custom packaging.

Properties

• CAS Number: 349-75-7
• Complexity: 144
• IUPAC Name: [3-(trifluoromethyl)phenyl]methanol
• InChI: InChI=1S/C8H7F3O/c9-8(10,11)7-3-1-2-6(4-7)5-12/h1-4,12H,5H2
• InChI Key: BXEHKCUWIODEDE-UHFFFAOYSA-N
• Exact Mass: 176.04489933
• Molecular Formula: C8H7F3O
• Molecular Weight: 176.14
• SMILES: C1=CC(=CC(=C1)C(F)(F)F)CO
• Topological: 20.2
• Monoisotopic Mass: 176.04489933
• Synonyms: 349-75-7, 3-(Trifluoromethyl)benzylic alcohol, EINECS 206-489-9, DTXSID20188455, 3-(Trifluoromethyl)benzenemethanol, DTXCID50110946, 206-489-9, 3-(Trifluoromethyl)benzyl alcohol, (3-(Trifluoromethyl)phenyl)methanol, 3-Trifluoromethylbenzyl alcohol, [3-(Trifluoromethyl)phenyl]methanol, 3-(trifluoromethyl)benzylalcohol, Benzenemethanol, 3-(trifluoromethyl)-, m-(Trifluoromethyl)benzyl alcohol, MFCD00004645, 3-Hydroxymethylbenzyltrifluoride, [3-(trifluoromethyl)phenyl]methan-1-ol, 3-Trifluorobenzyl alcohol, SCHEMBL2257, BT8MU69YY3, SCHEMBL95854, 3-trifluoromethylphenylmethanol, SCHEMBL127539, SCHEMBL20721999, SCHEMBL21268372, SCHEMBL27944323, BXEHKCUWIODEDE-UHFFFAOYSA-, (3-Trifluoromethylphenyl)methanol, FEGQGMVTLONIKW-UHFFFAOYSA-N, GFPGMKFRSIGLJU-UHFFFAOYSA-N, m-(trifluoromethyl)-benzyl alcohol, CS-D1160, (3-Trifluoromethyl-phenyl)-methanol, SBB064410, Benzyl alcohol, m-(trifluoromethyl)-, AKOS000249475, [3-(Trifluoromethyl)phenyl]methanol #, AC-9763, PS-8589, 3-(Trifluoromethyl)benzyl alcohol, 97%, SY015970, DB-001239, NS00041422, ST50406667, T1342, EN300-49130, F0001-1013, Z335244772, InChI=1/C8H7F3O/c9-8(10,11)7-3-1-2-6(4-7)5-12/h1-4,12H,5H2

Application

3-(Trifluoromethyl)benzylic alcohol is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of trifluoromethylated bioactive molecules. Its electron-deficient aromatic ring makes it valuable in agrochemical research for creating herbicides and fungicides. The compound also serves as a building block in material science for designing fluorinated polymers and liquid crystals with enhanced thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (95.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.