Description

3-(Trifluoromethoxy)aniline (CAS No. 1535-73-5) is a high-purity aromatic amine derivative with the molecular formula C₇H₆F₃NO. This compound features a trifluoromethoxy (-OCF₃) group meta-substituted to an aniline moiety, offering unique electronic and steric properties for advanced synthetic applications. Ideal for researchers in pharmaceuticals, agrochemicals, and materials science, this reagent serves as a versatile building block for the introduction of trifluoromethoxy-aniline motifs. Available in >98% purity (GC), it is supplied in sealed packaging under inert gas to ensure stability and longevity. Compatible with a wide range of coupling reactions, electrophilic substitutions, and heterocycle formations.

Properties

• CAS Number: 1535-73-5
• Complexity: 148
• IUPAC Name: 3-(trifluoromethoxy)aniline
• InChI: InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H,11H2
• InChI Key: SADHVOSOZBAAGL-UHFFFAOYSA-N
• Exact Mass: 177.04014830
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.12
• SMILES: C1=CC(=CC(=C1)OC(F)(F)F)N
• Topological: 35.3
• Monoisotopic Mass: 177.04014830
• Synonyms: 3-(Trifluoromethoxy)aniline, 1535-73-5, m-(trifluoromethoxy)aniline, Benzenamine, 3-(trifluoromethoxy)-, 3-(trifluoromethoxy)benzenamine, AZ5VZ8MT94, EINECS 216-256-3, DTXSID60165341, DTXCID8087832, 216-256-3, 3-trifluoromethoxyaniline, 3-trifluoromethoxy-phenylamine, MFCD00041511, 3-trifluoromethoxy aniline, m-Aminophenyl trifluoromethyl ether, EN300-28930, 3-(trifluoromethoxy)phenylamine, alpha,alpha,alpha-Trifluoro-m-anisidine, 3trifluoromethoxyaniline, m-trifluoromethoxyaniline, 3-trifluoromethoxy-aniline, UNII-AZ5VZ8MT94, SCHEMBL1523, SCHEMBL68084, 3-(Trifluoromethoxy) aniline, 3-(trifluoromethoxy)-aniline, aniline, 3-trifluoromethoxy-, SCHEMBL6599937, meta-trifluoromethoxy-phenylamine, 3-(trifluoromethoxyl)benzenamine, SCHEMBL27035492, SCHEMBL27724712, [3-(trifluoromethoxy)phenyl]amine, DWXPBLBCELSQOT-UHFFFAOYSA-N, QUPWXXHMPXWWKS-UHFFFAOYSA-N, BDBM626129, 3-(Trifluoromethoxy)aniline, 98%, SBB006603, STK802607, AKOS005145725, AC-3707, CS-W017377, PS-8569, SDCCGMLS-0066230.P001, FT105000, SY002366, DB-024350, NS00048235, ST45028477, T2255, Z278206764

Application

3-(Trifluoromethoxy)aniline is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly for compounds targeting central nervous system (CNS) disorders. Its trifluoromethoxy group enhances lipophilicity and metabolic stability, making it valuable in agrochemical formulations for crop protection. Additionally, this compound finds utility in materials science for designing liquid crystals and specialty polymers with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (85.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (85.4%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.