Description

3-Tolylboronic acid (CAS No. 17933-03-8) is a high-purity organoboron compound with the molecular formula C₇H₉BO₂, widely used as a versatile reagent in cross-coupling reactions such as Suzuki-Miyaura couplings. This white to off-white crystalline powder exhibits excellent stability and reactivity, making it indispensable in pharmaceutical, agrochemical, and materials science research. With a molecular weight of 135.96 g/mol, it is soluble in common organic solvents like THF, DMF, and methanol. Our product undergoes rigorous QC testing (HPLC, NMR) to ensure ≥97% purity, meeting the stringent demands of synthetic chemists. Packaged under inert gas to prevent degradation, it is available in quantities ranging from grams to kilograms with customizable bulk options.

Properties

• CAS Number: 17933-03-8
• Complexity: 106
• IUPAC Name: m-tolylboronic acid
• InChI: InChI=1S/C7H9BO2/c1-6-3-2-4-7(5-6)8(9)10/h2-5,9-10H,1H3
• InChI Key: BJQCPCFFYBKRLM-UHFFFAOYSA-N
• Exact Mass: 136.0695597
• Molecular Formula: C7H9BO2
• Molecular Weight: 135.96
• SMILES: B(C1=CC(=CC=C1)C)(O)O
• Topological: 40.5
• Monoisotopic Mass: 136.0695597
• Synonyms: 17933-03-8, 3-Tolylboronic acid, 3-Methylphenylboronic acid, DTXSID60370054, DTXCID50321090, 605-855-9, m-Tolylboronic acid, (3-Methylphenyl)boronic acid, 3-Methylbenzeneboronic Acid, 3-methylphenyl boronic acid, BORONIC ACID, B-(3-METHYLPHENYL)-, MFCD00040198, 3-Methyl phenyl boronic acid, m-methylphenylboronic acid, Boronic acid, (3-methylphenyl)-, m-tolyl boronic acid, M-TOLUENEBORONIC ACID, 3-tolyboronic acid, m-toluylboronic acid, 3-tolyl boronic acid, 3-tolyl-boronic acid, M-BORONOTOLUENE, NB5C2R9UJU, 3-methyl phenylboronic acid, 3-methyl-phenylboronic acid, m-Tolylboronic acid, 97%, 3-methylbenzene boronic acid, M-TOLYLDIHYDROXYBORANE, 3-methyl-phenyl boronic acid, 3-methyl-phenyl-boronic acid, 3-methyl benzene boronic acid, SCHEMBL102540, SCHEMBL219541, B-(3-Methylphenyl)boronic acid, BCP22770, SBB048058, STK503699, AKOS000266628, AB01795, AC-5358, AS-2512, CS-W007381, HY-W007381, NCGC00249455-01, SY002862, DB-014313, DB-366628, M1314, EN300-64373, F0001-0651, Z336079540, m-Tolylboronic acid (contains varying amounts of Anhydride)

3-Tolylboronic acid serves as a key intermediate in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds in drug discovery. It is employed in the synthesis of liquid crystals, OLED materials, and polymer catalysts due to its stable boronic moiety. Researchers also utilize it to modify peptides and develop boron neutron capture therapy (BNCT) agents. Its compatibility with palladium catalysts makes it ideal for creating complex aromatic systems under mild conditions.

Safety and Hazards

GHS Hazard Statements

• H315 (95.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (95.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (93.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (95.9%)
• Eye Irrit. 2 (95.9%)
• STOT SE 3 (93.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.