Description

3-Methoxybenzyl chloride (CAS 824-98-6) is a high-purity organic compound with the molecular formula C₈H₉ClO, widely utilized in pharmaceutical and chemical synthesis. This versatile reagent, also known as 1-(chloromethyl)-3-methoxybenzene, features a reactive chloromethyl group adjacent to a methoxy-substituted benzene ring, making it an excellent intermediate for nucleophilic substitution reactions. Its clear to pale-yellow liquid form is carefully stabilized for optimal performance in sensitive applications. Packaged under inert conditions to ensure longevity, our 3-Methoxybenzyl chloride is rigorously tested via GC, NMR, and HPLC to meet ≥98% purity standards, with trace moisture and impurities minimized for demanding research applications. Ideal for use in controlled environments, this compound is supplied in amber glass bottles with secure closures to prevent degradation.

Properties

• CAS Number: 824-98-6
• Complexity: 95.3
• IUPAC Name: 1-(chloromethyl)-3-methoxy-benzene
• InChI: InChI=1S/C8H9ClO/c1-10-8-4-2-3-7(5-8)6-9/h2-5H,6H2,1H3
• InChI Key: VGISFWWEOGVMED-UHFFFAOYSA-N
• Exact Mass: 156.0341926
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.61
• SMILES: COC1=CC=CC(=C1)CCl
• Topological: 9.2
• Monoisotopic Mass: 156.0341926
• Synonyms: 3-Methoxybenzyl chloride, 1-(Chloromethyl)-3-methoxybenzene, m-(Chloromethyl)anisole, m-Methoxybenzyl chloride, Anisole, m-(chloromethyl)-, Toluene, .alpha.-chloro-m-methocy-, EINECS 212-541-1, .alpha.-Chloro-3-methoxytoluene, DTXSID80231719, NSC 268684, alpha-Chloro-3-methoxytoluene, DTXCID60154210, Toluene, alpha-chloro-m-methocy-, 212-541-1, inchi=1/c8h9clo/c1-10-8-4-2-3-7(5-8)6-9/h2-5h,6h2,1h, vgisfwweogvmed-uhfffaoysa-n, 824-98-6, Benzene, 1-(chloromethyl)-3-methoxy-, 3-(Chloromethyl)anisole, 5-methoxybenzyl chloride, 3-(Chloromethyl)phenyl methyl ether, NSC-268684, 3-Methoxybenzylchloride, 3-(chloromethyl)-1-methoxybenzene, 1-(chloromethyl)-3-methoxy-benzene, MFCD00000907, 3-methoxybenzylchoride, 1-CHLOROMETHYL-3-METHOXYBENZENE, 3-methoxy benzylchloride, 3-methoxy benzyl chloride, 3-methoxy-benzyl chloride, NAG2TC49EB, alpha-Chloro-m-methoxytoluene, 3-methoxyphenylmethyl chloride, SCHEMBL228859, 3-Methoxybenzyl chloride, 97%, SCHEMBL28678472, (3-Methoxyphenyl)methyl chloride, 1-chloromethyl-3-methoxy-benzene, BCP18627, STR01218, 1-(chloro-methyl)-3-methoxybenzene, NSC268684, SBB040609, STL183312, AKOS000120691, CS-W017990, FM49121, DB-013567, M0820, NS00038209, ST50214007, EN300-21011, 3-(Chloromethyl)anisole;1-Chloromethyl-3-methoxybenzene, F0001-2115, Z104486106, 3-Methoxybenzyl chloride Stabilized over Potassium carbonate

Application

3-Methoxybenzyl chloride serves as a key building block in the synthesis of fine chemicals, agrochemicals, and active pharmaceutical ingredients (APIs). It is commonly employed in the preparation of benzyl ethers, protected intermediates, and specialty ligands for catalysis. Researchers also utilize it in the development of fragrances, liquid crystals, and polymer modifiers due to its reactive chloromethyl group. Its stability under anhydrous conditions makes it suitable for Grignard reactions and other organometallic processes.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.