Description

(-)-3-Hydroxytetrahydrofuran (CAS: 86087-24-3) is a high-purity chiral compound with the molecular formula C₄H₈O₂, widely utilized in pharmaceutical synthesis, asymmetric catalysis, and advanced material research. This enantiomerically enriched tetrahydrofuran derivative serves as a versatile building block for the preparation of bioactive molecules, including antiviral agents, chiral ligands, and complex natural products. Its stereochemical purity (R-configuration) ensures precise control in stereoselective reactions, making it indispensable for researchers requiring high enantiomeric excess (ee) in synthetic pathways. Available with a guaranteed purity of ≥98%, this product is rigorously tested via GC, HPLC, and chiral analysis to meet the stringent demands of laboratory and industrial applications. Packaged under inert conditions to ensure stability, it is ideal for use in sensitive organic transformations, medicinal chemistry, and fine chemical production.

Properties

• CAS Number: 86087-24-3
• Complexity: 44.8
• IUPAC Name: (3R)-tetrahydrofuran-3-ol
• InChI: InChI=1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m1/s1
• InChI Key: XDPCNPCKDGQBAN-SCSAIBSYSA-N
• Exact Mass: 88.052429494
• Molecular Formula: C4H8O2
• Molecular Weight: 88.11
• SMILES: C1COC[C@@H]1O
• Topological: 29.5
• Monoisotopic Mass: 88.052429494
• Synonyms: (-)-3-Hydroxytetrahydrofuran, 86087-24-3, (R)-(-)-3-Hydroxytetrahydrofuran, (R)-TETRAHYDROFURAN-3-OL, (3R)-oxolan-3-ol, (R)-3-HYDROXYTETRAHYDROFURAN, (R)-(-)-tetrahydrofuran-3-ol, (3R)-Tetrahydrofuran-3-ol, 3-Furanol, tetrahydro-, (3R)-, MFCD00067101, (3R)-tetrahydro-3-furanol, (R)-(+)-3-Hydroxytetrahydrofuran, (R)-Tetrahydro-furan-3-ol, AUS5N27VPH, SCHEMBL329377, SCHEMBL939613, (R)-3-hydroxy-tetrahydrofuran, SCHEMBL23572886, 3-Hydroxytetrahydrofuran, (-)-, 3-Hydroxytetrahydrofuran, (R)-, 3-Furanol, tetrahydro-, (R)-, XDPCNPCKDGQBAN-SCSAIBSYSA-N, (-)-(r)-3-hydroxytetrahydrofuran, (R)-(-)-3-hydroxy tetrahydrofuran, (R)-(-)-3-hydroxy-tetrahydrofuran, BBL100951, STL554745, AKOS005256250, FH34210, PS-9390, (R)-(-)-TETRAHYDRO-3-FURANOL, AC-13894, (R)-(-)-3-Hydroxytetrahydrofuran, 98%, 2-Furanyl, tetrahydro-3-hydroxy-, (R)-, CS-0045411, H1332, EN300-94223

(-)-3-Hydroxytetrahydrofuran is primarily employed as a chiral intermediate in the synthesis of pharmaceuticals, such as protease inhibitors and antiviral drugs. Its hydroxyl group enables facile functionalization, while the tetrahydrofuran ring enhances metabolic stability in drug candidates. Researchers also leverage its stereochemistry to construct chiral ligands for asymmetric catalysis or as a scaffold for polymer and material science applications.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.