Description

3-Hydroxy-5-methoxybenzoic acid (CAS No. 19520-75-3) is a high-purity aromatic carboxylic acid derivative with the molecular formula C₈H₈O₄. This compound features both hydroxyl (-OH) and methoxy (-OCH₃) functional groups ortho to the carboxylic acid moiety, making it a versatile intermediate for organic synthesis and pharmaceutical research. Available in crystalline form with ≥98% purity (HPLC), it is ideal for use as a building block in medicinal chemistry, ligand design, and material science applications. Each batch is rigorously tested for identity, potency, and impurities (including residual solvents and heavy metals) to ensure compliance with research-grade standards. Suitable for use in NMR, LC-MS, and other analytical techniques.

Properties

• CAS Number: 19520-75-3
• Complexity: 168
• IUPAC Name: 3-hydroxy-5-methoxy-benzoic acid
• InChI: InChI=1S/C8H8O4/c1-12-7-3-5(8(10)11)2-6(9)4-7/h2-4,9H,1H3,(H,10,11)
• InChI Key: TUUBOHWZSQXCSW-UHFFFAOYSA-N
• Exact Mass: 168.04225873
• Molecular Formula: C8H8O4
• Molecular Weight: 168.15
• SMILES: COC1=CC(=CC(=C1)O)C(=O)O
• Topological: 66.8
• Monoisotopic Mass: 168.04225873
• Synonyms: 3-hydroxy-5-methoxybenzoic acid, 19520-75-3, DTXSID30428677, 3-hydroxy-5-methoxybenzoate, DTXCID50379511, CHEMBL2146904, MFCD06655980, AN-651/43284894, SCHEMBL618373, 3-hydroxy-5-methoxybenzoicacid, 3-hydroxy-5-methoxy-benzoic acid, CHEBI:193969, TUUBOHWZSQXCSW-UHFFFAOYSA-N, BDBM50391818, AKOS000277131, AB25434, AS-50131, DA-08627, CS-0336623, EN300-150713, O11013, Z1198169196

Application

3-Hydroxy-5-methoxybenzoic acid serves as a key synthon in the preparation of bioactive molecules, particularly in the development of antioxidant and anti-inflammatory agents. Its bifunctional structure allows for selective derivatization at the hydroxyl or carboxyl groups, enabling the synthesis of complex heterocycles or polymer precursors. Researchers also utilize it as a standard in chromatographic analysis of plant-derived phenolic compounds. In material science, it acts as a monomer for designing functionalized aromatic polyesters.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.