Description

3-Fluoropyridine-4-carboxylic acid (CAS No. 393-53-3) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₄FNO₂. This compound, also known as 3-Fluoroisonicotinic acid, is a versatile building block in pharmaceutical and agrochemical research. Its unique structure, featuring a fluorine atom at the 3-position and a carboxylic acid group at the 4-position of the pyridine ring, makes it an ideal intermediate for synthesizing bioactive molecules, ligands, and advanced materials. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder. Suitable for use in cross-coupling reactions, metal-organic frameworks (MOFs), and medicinal chemistry applications. Packaged under inert gas to ensure stability and longevity.

Properties

• CAS Number: 393-53-3
• Complexity: 140
• IUPAC Name: 3-fluoropyridine-4-carboxylic acid
• InChI: InChI=1S/C6H4FNO2/c7-5-3-8-2-1-4(5)6(9)10/h1-3H,(H,9,10)
• InChI Key: POLXLLIQWDBJMD-UHFFFAOYSA-N
• Exact Mass: 141.02260653
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.10
• SMILES: C1=CN=CC(=C1C(=O)O)F
• Topological: 50.2
• Monoisotopic Mass: 141.02260653
• Synonyms: 3-Fluoropyridine-4-carboxylic acid, 639-266-3, 3-Fluoroisonicotinic acid, 393-53-3, 3-Fluoro-4-pyridinecarboxylic acid, MFCD03789251, 4-Pyridinecarboxylic acid, 3-fluoro-, NSC402974, 3-Fluoroisonicotinicacid, 3-fluoro isonicotinic acid, 3-fluoro-isonicotinic acid, 3-fluoro-4-carboxypyridine, SCHEMBL82604, DTXSID10323070, POLXLLIQWDBJMD-UHFFFAOYSA-N, BCP22196, 3-fluoro-pyridine-4-carboxylic acid, BBL102517, SBB028460, STL556320, AKOS005254563, CS-W001559, NSC-402974, PS-9028, SB10495, AC-23126, BP-12627, SY021120, 3-Fluoro-4-pyridinecarboxylic acid, 97%, DB-006449, ST50823728, EN300-82886, F1905-7161, Z1270326283

Application

3-Fluoropyridine-4-carboxylic acid is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly for developing kinase inhibitors and antiviral agents. Its fluorinated pyridine core is valuable in agrochemical research for creating novel pesticides and herbicides. The compound also serves as a ligand in catalysis and a precursor for functionalized materials in organic electronics.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (90.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.