Description

3-Fluorophenylboronic Acid (CAS No. 768-35-4) is a high-purity boronic acid derivative with the molecular formula C₆H₆BFO₂, widely utilized in organic synthesis, pharmaceutical research, and material science. This compound, also known as (3-fluorophenyl)boronic acid, features a fluorine-substituted phenyl ring attached to a boronic acid functional group, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its high reactivity and stability under controlled conditions ensure excellent yields in the formation of carbon-carbon bonds. Suitable for laboratory and industrial-scale applications, our product is rigorously tested for purity (>98%) and consistency, packaged under inert conditions to prevent degradation. Ideal for researchers developing fluorinated aromatic compounds, drug intermediates, or advanced polymeric materials.

Properties

• CAS Number: 768-35-4
• Complexity: 110
• IUPAC Name: (3-fluorophenyl)boronic acid
• InChI: InChI=1S/C6H6BFO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H
• InChI Key: KNXQDJCZSVHEIW-UHFFFAOYSA-N
• Exact Mass: 140.0444878
• Molecular Formula: C6H6BFO2
• Molecular Weight: 139.92
• SMILES: B(C1=CC(=CC=C1)F)(O)O
• Topological: 40.5
• Monoisotopic Mass: 140.0444878
• Synonyms: 3-Fluorophenylboronic acid, 768-35-4, DTXSID10370069, DTXCID40321105, 616-400-9, (3-fluorophenyl)boronic acid, 3-Fluorobenzeneboronic acid, m-fluorophenylboronic acid, 3-fluorophenyl boronic acid, MFCD00236042, 3-FLUOROBENZYLBORONIC ACID, FPBA, Boronic acid, (3-fluorophenyl)-, m-fluorobenzeneboronic acid, M-FLUORO-BENZENEBORONIC ACID, (3-FLUOROPHENYL-1-YL)BORONIC ACID, 3-fluorphenylboronic acid, 3-flurophenylboronic acid, 3-flourophenylboronic acid, 3-fluorophenyl boronicacid, V2MKR4GV2B, (3-fluorophenyl)boronicacid, 3-fluoro phenylboronic acid, 3-fluoro-phenylboronic acid, 3-fluorophenyl-boronic acid, SCHEMBL4933, 3-flourobenzene boronic acid, 3-fluoro-benzeneboronic acid, 3-fluorobenzene boronic acid, 3-fluorobenzene-boronic acid, 3-fluoro-phenyl boronic acid, 3-fluoro-phenyl-boronic acid, 3-fluorophenyl dihydroxyborane, (3-fluoro-phenyl)boronic acid, (3-fluorophenyl) boronic acid, (3-fluorophenyl)-boronic acid, dihydroxy(3-fluorophenyl)borane, (3-fluoro-phenyl)-boronic acid, B-(3-fluorophenyl)-boronic acid, ALBB-006113, BCP13763, CS-D1463, SBB048069, STK503715, AKOS000266286, AB05340, AC-5355, AS-2592, FF12163, 3-Fluorophenylboronic acid, >=95.0%, NCGC00249457-01, BP-11411, SY002210, DB-010593, F0404, EN300-73570, F0001-3053, Z381540934

Application

3-Fluorophenylboronic acid is primarily used as a key reagent in Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds with fluorinated aromatic systems. It serves as a critical intermediate in pharmaceutical development, particularly for designing fluorinated drug candidates with enhanced metabolic stability. Additionally, this compound finds utility in materials science for creating fluorinated polymers and advanced electronic materials.

Safety and Hazards

GHS Hazard Statements

• H302 (61.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (47.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (47.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (42.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (80%)
• Skin Corr. 1B (20%)
• Eye Dam. 1 (20%)
• Aquatic Chronic 2 (20%)

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