Description

3-Fluorobenzylic Alcohol (CAS No. 456-47-3) is a high-purity fluorinated aromatic alcohol with the molecular formula C₇H₇FO. Also known as (3-Fluorophenyl)methanol or m-Fluorobenzyl alcohol, this compound is a versatile building block in organic synthesis and pharmaceutical research. Its structure features a fluorinated phenyl ring with a hydroxymethyl group at the meta position, offering unique reactivity for nucleophilic substitutions and cross-coupling reactions. This product is rigorously tested for purity (typically ≥98% by GC) and is available in various packaging options to suit laboratory-scale or bulk requirements. Ideal for researchers developing fluorinated drug candidates, agrochemicals, or specialty materials. Store in a cool, dry place under inert atmosphere to maintain stability.

Properties

• CAS Number: 456-47-3
• Complexity: 85
• IUPAC Name: (3-fluorophenyl)methanol
• InChI: InChI=1S/C7H7FO/c8-7-3-1-2-6(4-7)5-9/h1-4,9H,5H2
• InChI Key: QDHRSLFSDGCJFX-UHFFFAOYSA-N
• Exact Mass: 126.048093005
• Molecular Formula: C7H7FO
• Molecular Weight: 126.13
• SMILES: C1=CC(=CC(=C1)F)CO
• Topological: 20.2
• Monoisotopic Mass: 126.048093005
• Synonyms: 3-Fluorobenzyl alcohol, 456-47-3, (3-Fluorophenyl)methanol, m-Fluorobenzyl alcohol, Benzenemethanol, 3-fluoro-, 3-Fluorobenzylic alcohol, Benzyl alcohol, m-fluoro-, RH5YXR9U9B, EINECS 207-265-3, NSC-158273, CHEBI:156103, DTXSID30196566, NSC 158273, DTXCID70119057, 207-265-3, inchi=1/c7h7fo/c8-7-3-1-2-6(4-7)5-9/h1-4,9h,5h, 3-Fluorobenzylalcohol, MFCD00004631, (3-fluorophenyl)methan-1-ol, NSC 158273; m-Fluorobenzyl Alcohol; 3-Fluorobenzenemethanol; (3-Fluorophenyl)methanol, 3-florobenzyl alcohol, 3-fluoro-benzylalcohol, 3-flouro-benzyl alcohol, 3-fluoro-benzyl alcohol, 3-(Fluoro)benzylalcohol, UNII-RH5YXR9U9B, (3-fluorophenyl) methanol, (3-fluorophenyl)-methanol, (3-Fluoro-phenyl)-methanol, (3-Fluorophenyl)methanol #, SCHEMBL38187, SCHEMBL94694, SCHEMBL128729, SCHEMBL147803, 3-Fluorobenzyl alcohol, 98%, SCHEMBL4074532, SCHEMBL17046385, SCHEMBL27757916, NSC158273, SBB064188, AKOS000119384, CS-W021926, AC-26191, SY008446, DB-001256, F0370, NS00043598, ST51028325, EN300-20242, Q18472862, Z104477458

Application

3-Fluorobenzylic alcohol serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, including antipsychotics and anti-inflammatory agents. Its hydroxyl group enables esterification or etherification, while the fluorine atom enhances metabolic stability in drug molecules. Researchers also utilize it to prepare fluorinated liquid crystals and polymers with tailored optical/electronic properties. In agrochemistry, it acts as a precursor for herbicides and pesticides with improved environmental persistence.

Safety and Hazards

GHS Hazard Statements

• H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (80%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (60%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (20%)
• Skin Irrit. 2 (80%)
• Eye Irrit. 2A (80%)
• Acute Tox. 4 (20%)
• STOT SE 3 (60%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.