Description

3-Fluorobenzylamine (CAS No. 100-82-3) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN and IUPAC name (3-fluorophenyl)methanamine. This specialized chemical is widely utilized in pharmaceutical synthesis, agrochemical development, and advanced material research due to its reactive primary amine group and fluorine substitution at the meta position. Our product is rigorously tested to ensure ≥98% purity (GC) with controlled moisture content, making it ideal for sensitive applications. Supplied in amber glass bottles under inert gas to prevent degradation, this compound is a versatile building block for heterocyclic compounds, chiral auxiliaries, and fluorinated analogs of bioactive molecules. Synonyms include m-Fluorobenzylamine, meta-Fluorobenzylamine, and Benzenemethanamine, 3-fluoro-.

Properties

• CAS Number: 100-82-3
• Complexity: 85
• IUPAC Name: (3-fluorophenyl)methanamine
• InChI: InChI=1S/C7H8FN/c8-7-3-1-2-6(4-7)5-9/h1-4H,5,9H2
• InChI Key: QVSVMNXRLWSNGS-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: C1=CC(=CC(=C1)F)CN
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 3-Fluorobenzylamine, Benzenemethanamine, 3-fluoro-, m-Fluorobenzylamine, Benzylamine, m-fluoro-, meta-Fluorobenzylamine, EINECS 202-891-3, DTXSID8059219, DTXCID3032460, 202-891-3, qvsvmnxrlwsngs-uhfffaoysa-n, 100-82-3, (3-Fluorophenyl)methanamine, 1-(3-fluorophenyl)methanamine, 3-fluorobenzyl amine, 3-Fluoro-benzylamine, MFCD00008113, (3-fluorophenyl)methylamine, CHEMBL12722, m-fluorobenzyl amine, 3-Fluorobenzenemethanamine, (3-fluorobenzyl)amine, benzylamine, 3-fluoro-, 3-fluorophenylmethylamine, 3-Fluorobenzylamine, 97%, SCHEMBL20927, SCHEMBL42966, (3-Fluorophenyl)methanamine #, 6MGA6423TQ, SCHEMBL1197296, SCHEMBL1244409, SCHEMBL2073678, SCHEMBL2167726, SCHEMBL27568249, SCHEMBL27615294, ALBB-007577, BDBM50623068, CK2419, SBB028218, STK504635, AKOS000132809, AC-9770, CS-W020632, PB47628, PS-9202, DB-000191, F0539, NS00041166, ST50947315, EN300-33064, Q27467952, Z54748277

Application

3-Fluorobenzylamine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly for CNS-targeting drugs and PET radiotracers. Its electron-withdrawing fluorine moiety enhances metabolic stability in drug candidates, while the reactive amine group facilitates peptide coupling and heterocycle formation. Researchers employ this compound in Suzuki-Miyaura cross-coupling reactions to create biaryl structures with improved pharmacokinetic properties.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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