Description

3-Fluorobenzyl chloride (CAS No. 456-42-8) is a high-purity organic compound with the molecular formula C₇H₆ClF and IUPAC name 1-(chloromethyl)-3-fluorobenzene. This versatile reagent is widely used in pharmaceutical, agrochemical, and material science research due to its reactive benzyl chloride and fluorine substituent. Our product is rigorously tested to ensure ≥98% purity (GC), with strict quality control for moisture, residual solvents, and heavy metals. Supplied in amber glass bottles under inert gas to prevent degradation, it is ideal for nucleophilic substitution, coupling reactions, and as a building block for fluorinated compounds. Available in quantities from 1g to 10kg with customizable packaging. SDS and CoA provided upon request.

Properties

• CAS Number: 456-42-8
• Complexity: 85
• IUPAC Name: 1-(chloromethyl)-3-fluoro-benzene
• InChI: InChI=1S/C7H6ClF/c8-5-6-2-1-3-7(9)4-6/h1-4H,5H2
• InChI Key: XBDXMDVEZLOGMC-UHFFFAOYSA-N
• Exact Mass: 144.0142060
• Molecular Formula: C7H6ClF
• Molecular Weight: 144.57
• SMILES: C1=CC(=CC(=C1)F)CCl
• Monoisotopic Mass: 144.0142060
• Physical Description: Colorless liquid with a pungent odor;
• Vapor Pressure: 0.99 [mmHg]
• Synonyms: 3-Fluorobenzyl chloride, 456-42-8, Benzene, 1-(chloromethyl)-3-fluoro-, EINECS 207-264-8, NSC 60720, 3-Fluorophenylmethyl chloride, DTXSID4060026, mFluorobenzyl chloride, alphaChloromfluorotoluene, alphaChloro3fluorotoluene, Toluene, alphachloromfluoro, 1(Chloromethyl)3fluorobenzene, DTXCID8040438, Benzene, 1(chloromethyl)3fluoro, Toluene, alphachloromfluoro (8CI), un2920, xbdxmdvezlogmc-uhfffaoysa-n, 1-(Chloromethyl)-3-fluorobenzene, M-FLUOROBENZYL CHLORIDE, 3-Fluorobenzylchloride, 1-Chloromethyl-3-fluoro-benzene, Toluene, .alpha.-chloro-m-fluoro-, .alpha.-Chloro-m-fluorotoluene, .alpha.-Chloro-3-fluorotoluene, 3-(chloromethyl)-1-fluorobenzene, NSC-60720, alpha-Chloro-3-fluorotoluene, alpha-Chloro-m-fluorotoluene, MFCD00000904, 3-flurobenzylchloride, m-fluorobenzylchloride, 3-flourobenzyl chloride, m-fluoro-benzyl chloride, 3-fluoro-benzyl chloride, DXT56E2KBP, SCHEMBL70652, 3-Fluorobenzyl chloride, 96%, SCHEMBL3645266, SCHEMBL21194005, SCHEMBL27748219, SCHEMBL27795007, SCHEMBL28203687, Toluene, alpha-chloro-m-fluoro-, CS-D0813, NSC60720, SBB040605, STL195659, AKOS000120643, AC-26193, DB-024085, F0210, NS00126547, ST50214003, EN300-18208, A22404, F2190-0252, m-Fluorobenzyl chloride; alpha-Chloro-m-fluorotoluene; 1-(Chloromethyl)-3-fluoro-benzene, -(chloromethyl)-3-fluoro-benzen;3-Fluorophenylmethyl chloride;Toluene, alpha-chloro-m-fluoro-

Application

3-Fluorobenzyl chloride serves as a key intermediate in synthesizing fluorinated pharmaceuticals, including CNS agents and anti-inflammatory drugs. Its reactive chloromethyl group enables facile functionalization for cross-coupling or amination reactions in medicinal chemistry. The compound is also employed in liquid crystal and polymer research, where the fluorine moiety modifies electronic properties. Researchers utilize it to prepare fluorinated analogs of bioactive molecules for structure-activity relationship (SAR) studies.

Safety and Hazards

GHS Hazard Statements

• H226 (98%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98%)
• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.